TY  - JOUR
AU  - Giegling, Ina
AU  - Hosak, Ladislav
AU  - Mössner, Rainald
AU  - Serretti, Alessandro
AU  - Bellivier, Frank
AU  - Claes, Stephan
AU  - Collier, David A.
AU  - Corrales, Alejo
AU  - DeLisi, Lynn E.
AU  - Gallo, Carla
AU  - Gill, Michael
AU  - Kennedy, James L.
AU  - Leboyer, Marion
AU  - Maier, Wolfgang
AU  - Marquez, Miguel
AU  - Massat, Isabelle
AU  - Mors, Ole
AU  - Muglia, Pierandrea
AU  - Nöthen, Markus M.
AU  - Ospina-Duque, Jorge
AU  - Owen, Michael J.
AU  - Propping, Peter
AU  - Shi, YongYong
AU  - St Clair, David
AU  - Thibaut, Florence
AU  - Cichon, Sven
AU  - Mendlewicz, Julien
AU  - O'Donovan, Michael C.
AU  - Rujescu, Dan
TI  - Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics
JO  - The world journal of biological psychiatry
VL  - 18
IS  - 7
SN  - 1814-1412
CY  - Abingdon
PB  - Taylor & Francis Group
M1  - FZJ-2017-02047
SP  - 492-505
PY  - 2017
AB  - AbstractObjectives: Schizophrenia is a severe psychiatric disease affecting about 1% of the general population. The relative contribution of genetic factors has been estimated to be up to 80%. The mode of inheritance is complex, non-Mendelian, and in most cases involving the combined action of large numbers of genes.Methods: This review summarises recent efforts to identify genetic variants associated with schizophrenia detected, e.g., through genome-wide association studies, studies on copy-number variants or next-generation sequencing.Results: A large, new body of evidence on genetics of schizophrenia has accumulated over recent years. Many new robustly associated genetic loci have been detected. Furthermore, there is consensus that at least a dozen microdeletions and microduplications contribute to the disease. Genetic overlap between schizophrenia, other psychiatric disorders, and neurodevelopmental syndromes raised new questions regarding the current classification of psychiatric and neurodevelopmental diseases.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000410902200002
C6  - pmid:28112043
DO  - DOI:10.1080/15622975.2016.1268715
UR  - https://juser.fz-juelich.de/record/828033
ER  -