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| 001 | 828033 | ||
| 005 | 20210129225959.0 | ||
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| 100 | 1 | _ | |a Giegling, Ina |b 0 |
| 245 | _ | _ | |a Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics |
| 260 | _ | _ | |a Abingdon |c 2017 |b Taylor & Francis Group |
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| 520 | _ | _ | |a AbstractObjectives: Schizophrenia is a severe psychiatric disease affecting about 1% of the general population. The relative contribution of genetic factors has been estimated to be up to 80%. The mode of inheritance is complex, non-Mendelian, and in most cases involving the combined action of large numbers of genes.Methods: This review summarises recent efforts to identify genetic variants associated with schizophrenia detected, e.g., through genome-wide association studies, studies on copy-number variants or next-generation sequencing.Results: A large, new body of evidence on genetics of schizophrenia has accumulated over recent years. Many new robustly associated genetic loci have been detected. Furthermore, there is consensus that at least a dozen microdeletions and microduplications contribute to the disease. Genetic overlap between schizophrenia, other psychiatric disorders, and neurodevelopmental syndromes raised new questions regarding the current classification of psychiatric and neurodevelopmental diseases. |
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| 700 | 1 | _ | |a Hosak, Ladislav |b 1 |
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| 700 | 1 | _ | |a Bellivier, Frank |b 4 |
| 700 | 1 | _ | |a Claes, Stephan |b 5 |
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| 700 | 1 | _ | |a Corrales, Alejo |b 7 |
| 700 | 1 | _ | |a DeLisi, Lynn E. |b 8 |
| 700 | 1 | _ | |a Gallo, Carla |b 9 |
| 700 | 1 | _ | |a Gill, Michael |b 10 |
| 700 | 1 | _ | |a Kennedy, James L. |b 11 |
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| 700 | 1 | _ | |a Nöthen, Markus M. |b 18 |
| 700 | 1 | _ | |a Ospina-Duque, Jorge |b 19 |
| 700 | 1 | _ | |a Owen, Michael J. |b 20 |
| 700 | 1 | _ | |a Propping, Peter |b 21 |
| 700 | 1 | _ | |a Shi, YongYong |b 22 |
| 700 | 1 | _ | |a St Clair, David |b 23 |
| 700 | 1 | _ | |a Thibaut, Florence |b 24 |
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| 700 | 1 | _ | |a Mendlewicz, Julien |b 26 |
| 700 | 1 | _ | |a O'Donovan, Michael C. |b 27 |
| 700 | 1 | _ | |a Rujescu, Dan |0 P:(DE-HGF)0 |b 28 |e Corresponding author |
| 773 | _ | _ | |a 10.1080/15622975.2016.1268715 |g p. 1 - 14 |0 PERI:(DE-600)2170223-8 |n 7 |p 492-505 |t The world journal of biological psychiatry |v 18 |y 2017 |x 1814-1412 |
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