%0 Journal Article
%A GENON, Sarah
%A Reid, Andrew
%A Li, Hai
%A Fan, Lingzhong
%A Müller, Veronika
%A Cieslik, Edna
%A Hoffstaedter, Felix
%A Langner, Robert
%A Grefkes, Christian
%A Laird, Angela R.
%A Fox, Peter T.
%A Jiang, Tianzi
%A Amunts, Katrin
%A Eickhoff, Simon
%T The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization
%J NeuroImage
%V 170
%@ 1053-8119
%C Orlando, Fla.
%I Academic Press
%M FZJ-2017-02052
%P 400-411
%D 2018
%X Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro-dorsal distinction dividing it into five subregions: rostral, central, caudal, ventral and dorsal. The present study assessed whether a similar organization is present in the left hemisphere, by capitalizing on a multimodal data-driven approach combining connectivity-based parcellation (CBP) based on meta-analytic modeling, resting-state functional connectivity, and probabilistic diffusion tractography. The resulting PMd modules were then characterized based on multimodal functional connectivity and a quantitative analysis of associated behavioral functions. Analyzing the clusters consistent across all modalities revealed an organization of the left PMd that mirrored its right counterpart to a large degree. Again, caudal, central and rostral modules reflected a cognitive-motor gradient and a premotor eye-field was found in the ventral part of the left PMd. In addition, a distinct module linked to abstract cognitive functions was observed in the rostro-ventral left PMd across all CBP modalities, implying greater differentiation of higher cognitive functions for the left than the right PMd.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28213119
%U <Go to ISI:>//WOS:000429940900032
%R 10.1016/j.neuroimage.2017.02.034
%U https://juser.fz-juelich.de/record/828038