TY  - JOUR
AU  - GENON, Sarah
AU  - Reid, Andrew
AU  - Li, Hai
AU  - Fan, Lingzhong
AU  - Müller, Veronika
AU  - Cieslik, Edna
AU  - Hoffstaedter, Felix
AU  - Langner, Robert
AU  - Grefkes, Christian
AU  - Laird, Angela R.
AU  - Fox, Peter T.
AU  - Jiang, Tianzi
AU  - Amunts, Katrin
AU  - Eickhoff, Simon
TI  - The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization
JO  - NeuroImage
VL  - 170
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2017-02052
SP  - 400-411
PY  - 2018
AB  - Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro-dorsal distinction dividing it into five subregions: rostral, central, caudal, ventral and dorsal. The present study assessed whether a similar organization is present in the left hemisphere, by capitalizing on a multimodal data-driven approach combining connectivity-based parcellation (CBP) based on meta-analytic modeling, resting-state functional connectivity, and probabilistic diffusion tractography. The resulting PMd modules were then characterized based on multimodal functional connectivity and a quantitative analysis of associated behavioral functions. Analyzing the clusters consistent across all modalities revealed an organization of the left PMd that mirrored its right counterpart to a large degree. Again, caudal, central and rostral modules reflected a cognitive-motor gradient and a premotor eye-field was found in the ventral part of the left PMd. In addition, a distinct module linked to abstract cognitive functions was observed in the rostro-ventral left PMd across all CBP modalities, implying greater differentiation of higher cognitive functions for the left than the right PMd.
LB  - PUB:(DE-HGF)16
C6  - pmid:28213119
UR  - <Go to ISI:>//WOS:000429940900032
DO  - DOI:10.1016/j.neuroimage.2017.02.034
UR  - https://juser.fz-juelich.de/record/828038
ER  -