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@ARTICLE{Popovych:828406,
      author       = {Popovych, Oleksandr V. and Lysyansky, Borys and Rosenblum,
                      Michael and Pikovsky, Arkady and Tass, Peter A.},
      title        = {{P}ulsatile desynchronizing delayed feedback for
                      closed-loop deep brain stimulation},
      journal      = {PLoS one},
      volume       = {12},
      number       = {3},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {FZJ-2017-02367},
      pages        = {e0173363 -},
      year         = {2017},
      abstract     = {High-frequency (HF) deep brain stimulation (DBS) is the
                      gold standard for the treatment of medically refractory
                      movement disorders like Parkinson’s disease, essential
                      tremor, and dystonia, with a significant potential for
                      application to other neurological diseases. The standard
                      setup of HF DBS utilizes an open-loop stimulation protocol,
                      where a permanent HF electrical pulse train is administered
                      to the brain target areas irrespectively of the ongoing
                      neuronal dynamics. Recent experimental and clinical studies
                      demonstrate that a closed-loop, adaptive DBS might be
                      superior to the open-loop setup. We here combine the notion
                      of the adaptive high-frequency stimulation approach, that
                      aims at delivering stimulation adapted to the extent of
                      appropriately detected biomarkers, with specifically
                      desynchronizing stimulation protocols. To this end, we
                      extend the delayed feedback stimulation methods, which are
                      intrinsically closed-loop techniques and specifically
                      designed to desynchronize abnormal neuronal synchronization,
                      to pulsatile electrical brain stimulation. We show that
                      permanent pulsatile high-frequency stimulation subjected to
                      an amplitude modulation by linear or nonlinear delayed
                      feedback methods can effectively and robustly desynchronize
                      a STN-GPe network of model neurons and suggest this approach
                      for desynchronizing closed-loop DBS.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28273176},
      UT           = {WOS:000396073700055},
      doi          = {10.1371/journal.pone.0173363},
      url          = {https://juser.fz-juelich.de/record/828406},
}