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@ARTICLE{Toma:828467,
author = {Toma, Mana and Belu, Andreea and Mayer, Dirk and
Offenhäusser, Andreas},
title = {{F}lexible {G}old {N}anocone {A}rray {S}urfaces as a {T}ool
for {R}egulating {N}euronal {B}ehavior},
journal = {Small},
volume = {13},
number = {24},
issn = {1613-6810},
address = {Weinheim},
publisher = {Wiley-VCH},
reportid = {FZJ-2017-02426},
pages = {1700629},
year = {2017},
abstract = {Accelerated neurite outgrowth of rat cortical neurons on a
flexible and inexpensive substrate functionalized with gold
nanocone arrays is reported. The gold nanocone arrays are
fabricated on Teflon films by a bottom-up approach based on
colloidal lithography followed by deposition of a thin gold
layer. The geometry of nanocone arrays including height and
pitch is controlled by the overall etching time and template
polystyrene beads size. Fluorescence microscopy studies
reveal high viability and significant morphological changes
of the neurons on the structured surfaces. The elongation
degree of neurite is maximized on the nanocone arrays
created with 1 µm polystyrene beads by a factor of two with
respect to the control. Furthermore, the interface between
the neurons and the nanocones is investigated by scanning
electron microscopy and focused ion beam cross-sectioning.
The detailed observation of the neuron/nanocone interfaces
reveals the morphological similarity between the nanocone
tips and the neuronal processes, the existence of interspace
at the interface between the cell body and the nanocones,
and neurite bridging among the neighboring structures, which
may induce the acceleration of neurite outgrowth. The
flexible gold nanocone arrays can be a good supporting
substrate of neuron culture with noble electrical and
optical properties.},
cin = {ICS-8},
ddc = {540},
cid = {I:(DE-Juel1)ICS-8-20110106},
pnm = {552 - Engineering Cell Function (POF3-552)},
pid = {G:(DE-HGF)POF3-552},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000403805900013},
pubmed = {pmid:28464550},
doi = {10.1002/smll.201700629},
url = {https://juser.fz-juelich.de/record/828467},
}