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@ARTICLE{Binder:829124,
      author       = {Binder, Ellen and Dovern, Anna and Hesse, Maike and Ebke,
                      Markus and Karbe, Hans and Saliger, Jochen and Fink, Gereon
                      R. and Weiss-Blankenhorn, Peter},
      title        = {{L}esion evidence for a human mirror neuron system},
      journal      = {Cortex},
      volume       = {90},
      issn         = {0010-9452},
      address      = {Paris},
      publisher    = {Elsevier Masson},
      reportid     = {FZJ-2017-02931},
      pages        = {125 - 137},
      year         = {2017},
      abstract     = {More than two decades ago, the mirror neuron system (MNS)
                      was discovered in non-human primates: Single-cell recordings
                      detected visuo-motor neurons that discharged not only when
                      the monkey performed an action, but also when it observed
                      conspecifics performing the same action. It has been
                      proposed that a fronto-parietal circuitry constitutes the
                      human homolog of the MNS. However, the functional role of a
                      human MNS (i.e., whether it is functionally necessary for
                      imitation or action understanding) to date remains
                      controversial. We here examined how patients with left
                      hemisphere (LH) stroke imitate, recognize, and comprehend
                      intransitive meaningful limb actions. In particular, we
                      investigated whether apraxic patients with lesions affecting
                      key nodes of the putative human MNS show deficits in action
                      imitation, action recognition, and action comprehension to a
                      similar degree – as predicted by the MNS hypothesis.
                      Behavioral results showed that patients with apraxia (n =
                      18) indeed performed significantly worse in all three motor
                      cognitive tasks compared to non-apraxic patients (n = 26)
                      and healthy controls (n = 19), whose performance did not
                      differ significantly. Lesions of the apraxic (compared to
                      non-apraxic) patients with LH stroke affected more
                      frequently key regions of the putative human MNS, i.e., the
                      left inferior frontal, superior temporal, and supramarginal
                      gyri as well as the inferior parietal lobe (p < .01, false
                      discovery rate – FDR-corrected). Albeit largely
                      overlapping, voxel-based lesion-symptom mapping (VLSM)
                      revealed that deficits in gesture comprehension were mainly
                      associated with lesions of more anterior parts of the MNS,
                      whereas lesions located more posteriorly mainly resulted in
                      gesture imitation deficits (p < .05, FDR-corrected). Our
                      clinical data support key hypotheses derived from the notion
                      of a human MNS: LH lesions to the MNS core regions affected
                      – critically and to a similar extent – the imitation,
                      recognition, and comprehension of meaningful actions.},
      cin          = {INM-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000403029900011},
      pubmed       = {pmid:28391066},
      doi          = {10.1016/j.cortex.2017.02.008},
      url          = {https://juser.fz-juelich.de/record/829124},
}