%0 Journal Article
%A Elmenhorst, David
%A Elmenhorst, Eva-Maria
%A Hennecke, Eva
%A Kroll, Tina
%A Matusch, Andreas
%A Aeschbach, Daniel
%A Bauer, Andreas
%T Recovery sleep after extended wakefulness restores elevated A 1 adenosine receptor availability in the human brain
%J Proceedings of the National Academy of Sciences of the United States of America
%V 114
%N 16
%@ 1091-6490
%C Washington, DC
%I National Acad. of Sciences
%M FZJ-2017-03031
%P 4243-4248/201614677
%D 2017
%X Adenosine and functional A1 adenosine receptor (A1AR) availability are supposed to mediate sleep–wake regulation and cognitive performance. We hypothesized that cerebral A1AR availability after an extended wake period decreases to a well-rested state after recovery sleep. [18F]CPFPX positron emission tomography was used to quantify A1AR availability in 15 healthy male adults after 52 h of sleep deprivation and following 14 h of recovery sleep. Data were additionally compared with A1AR values after 8 h of baseline sleep from an earlier dataset. Polysomnography, cognitive performance, and sleepiness were monitored. Recovery from sleep deprivation was associated with a decrease in A1AR availability in several brain regions, ranging from 11% (insula) to 14% (striatum). A1AR availabilities after recovery did not differ from baseline sleep in the control group. The degree of performance impairment, sleepiness, and homeostatic sleep-pressure response to sleep deprivation correlated negatively with the decrease in A1AR availability. Sleep deprivation resulted in a higher A1AR availability in the human brain. The increase that was observed after 52 h of wakefulness was restored to control levels during a 14-h recovery sleep episode. Individuals with a large increase in A1AR availability were more resilient to sleep-loss effects than those with a subtle increase. This pattern implies that differences in endogenous adenosine and A1AR availability might be causal for individual responses to sleep loss.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000399387400069
%$ pmid:28373571
%R 10.1073/pnas.1614677114
%U https://juser.fz-juelich.de/record/829311