TY  - JOUR
AU  - Elmenhorst, David
AU  - Elmenhorst, Eva-Maria
AU  - Hennecke, Eva
AU  - Kroll, Tina
AU  - Matusch, Andreas
AU  - Aeschbach, Daniel
AU  - Bauer, Andreas
TI  - Recovery sleep after extended wakefulness restores elevated A 1 adenosine receptor availability in the human brain
JO  - Proceedings of the National Academy of Sciences of the United States of America
VL  - 114
IS  - 16
SN  - 1091-6490
CY  - Washington, DC
PB  - National Acad. of Sciences
M1  - FZJ-2017-03031
SP  - 4243-4248/201614677
PY  - 2017
AB  - Adenosine and functional A1 adenosine receptor (A1AR) availability are supposed to mediate sleep–wake regulation and cognitive performance. We hypothesized that cerebral A1AR availability after an extended wake period decreases to a well-rested state after recovery sleep. [18F]CPFPX positron emission tomography was used to quantify A1AR availability in 15 healthy male adults after 52 h of sleep deprivation and following 14 h of recovery sleep. Data were additionally compared with A1AR values after 8 h of baseline sleep from an earlier dataset. Polysomnography, cognitive performance, and sleepiness were monitored. Recovery from sleep deprivation was associated with a decrease in A1AR availability in several brain regions, ranging from 11% (insula) to 14% (striatum). A1AR availabilities after recovery did not differ from baseline sleep in the control group. The degree of performance impairment, sleepiness, and homeostatic sleep-pressure response to sleep deprivation correlated negatively with the decrease in A1AR availability. Sleep deprivation resulted in a higher A1AR availability in the human brain. The increase that was observed after 52 h of wakefulness was restored to control levels during a 14-h recovery sleep episode. Individuals with a large increase in A1AR availability were more resilient to sleep-loss effects than those with a subtle increase. This pattern implies that differences in endogenous adenosine and A1AR availability might be causal for individual responses to sleep loss.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000399387400069
C6  - pmid:28373571
DO  - DOI:10.1073/pnas.1614677114
UR  - https://juser.fz-juelich.de/record/829311
ER  -