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| 001 | 829311 | ||
| 005 | 20220930130120.0 | ||
| 024 | 7 | _ | |a 10.1073/pnas.1614677114 |2 doi |
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| 100 | 1 | _ | |a Elmenhorst, David |0 P:(DE-Juel1)131679 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Recovery sleep after extended wakefulness restores elevated A 1 adenosine receptor availability in the human brain |
| 260 | _ | _ | |a Washington, DC |c 2017 |b National Acad. of Sciences |
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| 520 | _ | _ | |a Adenosine and functional A1 adenosine receptor (A1AR) availability are supposed to mediate sleep–wake regulation and cognitive performance. We hypothesized that cerebral A1AR availability after an extended wake period decreases to a well-rested state after recovery sleep. [18F]CPFPX positron emission tomography was used to quantify A1AR availability in 15 healthy male adults after 52 h of sleep deprivation and following 14 h of recovery sleep. Data were additionally compared with A1AR values after 8 h of baseline sleep from an earlier dataset. Polysomnography, cognitive performance, and sleepiness were monitored. Recovery from sleep deprivation was associated with a decrease in A1AR availability in several brain regions, ranging from 11% (insula) to 14% (striatum). A1AR availabilities after recovery did not differ from baseline sleep in the control group. The degree of performance impairment, sleepiness, and homeostatic sleep-pressure response to sleep deprivation correlated negatively with the decrease in A1AR availability. Sleep deprivation resulted in a higher A1AR availability in the human brain. The increase that was observed after 52 h of wakefulness was restored to control levels during a 14-h recovery sleep episode. Individuals with a large increase in A1AR availability were more resilient to sleep-loss effects than those with a subtle increase. This pattern implies that differences in endogenous adenosine and A1AR availability might be causal for individual responses to sleep loss. |
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| 773 | _ | _ | |a 10.1073/pnas.1614677114 |g p. 201614677 - |0 PERI:(DE-600)1461794-8 |n 16 |p 4243-4248/201614677 |t Proceedings of the National Academy of Sciences of the United States of America |v 114 |y 2017 |x 1091-6490 |
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