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000829362 1001_ $$0P:(DE-Juel1)161571$$aOwen, Michael$$b0$$eCorresponding author
000829362 245__ $$aProtein Stability and Unfolding Following Glycine Radical Formation
000829362 260__ $$aBasel$$bMDPI$$c2017
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000829362 520__ $$aGlycine (Gly) residues are particularly susceptible to hydrogen abstraction; which results in the formation of the capto-dative stabilized Cα-centered Gly radical (GLR) on the protein backbone. We examined the effect of GLR formation on the structure of the Trp cage; tryptophan zipper; and the villin headpiece; three fast-folding and stable miniproteins; using all-atom (OPLS-AA) molecular dynamics simulations. Radicalization changes the conformation of the GLR residue and affects both neighboring residues but did not affect the stability of the Trp zipper. The stability of helices away from the radical center in villin were also affected by radicalization; and GLR in place of Gly15 caused the Trp cage to unfold within 1 µs. These results provide new evidence on the destabilizing effects of protein oxidation by reactive oxygen species.
000829362 536__ $$0G:(DE-HGF)POF3-553$$a553 - Physical Basis of Diseases (POF3-553)$$cPOF3-553$$fPOF III$$x0
000829362 7001_ $$0P:(DE-HGF)0$$aCsizmadia, Imre G.$$b1
000829362 7001_ $$0P:(DE-HGF)0$$aViskolcz, Béla$$b2
000829362 7001_ $$0P:(DE-Juel1)132024$$aStrodel, Birgit$$b3
000829362 770__ $$aBiomolecular Simulations
000829362 773__ $$0PERI:(DE-600)2008644-1$$a10.3390/molecules22040655$$n4$$p655$$tMolecules$$v22$$x1420-3049$$y2017
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