000829378 001__ 829378
000829378 005__ 20210129230258.0
000829378 020__ $$a978-3-319-17274-3 (print)
000829378 020__ $$a978-3-319-17275-0 (electronic)
000829378 0247_ $$2doi$$a10.1007/978-3-319-17275-0_9
000829378 0247_ $$2WOS$$aWOS:000365949800010
000829378 037__ $$aFZJ-2017-03091
000829378 1001_ $$0P:(DE-HGF)0$$aVerma, Rama Shanker$$b0$$eEditor
000829378 245__ $$aTherapeutic Impact of Immune Responses in Cancer
000829378 260__ $$aCham$$bSpringer International Publishing$$c2015
000829378 29510 $$aResistance to Immunotoxins in Cancer Therapy / Verma, Rama Shanker (Editor)   ; Cham : Springer International Publishing, 2015, Chapter 9 ; ISSN: 2196-5501=2196-551X ; ISBN: 978-3-319-17274-3=978-3-319-17275-0 ; doi:10.1007/978-3-319-17275-0
000829378 300__ $$a221 - 245
000829378 3367_ $$2ORCID$$aBOOK_CHAPTER
000829378 3367_ $$07$$2EndNote$$aBook Section
000829378 3367_ $$2DRIVER$$abookPart
000829378 3367_ $$2BibTeX$$aINBOOK
000829378 3367_ $$2DataCite$$aOutput Types/Book chapter
000829378 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1493015668_17728
000829378 4900_ $$aResistance to Targeted Anti-Cancer Therapeutics$$v6
000829378 520__ $$aTherapeutic targeted oncoimmunology has a long history reaching back to the nineteenth century and represents the basis of modern tumor immunology. Cell biological and molecular genetic techniques have uncovered crucial cellular and molecular mechanisms underlying effective cancer immunotherapies used in the clinic. To illustrate the scientific way that led to actual insights into the molecular and cellular approaches realized in recent cancer therapies, this chapter introduces into the history of oncoimmunology. Experimental findings of adoptive cell transfer-based cancer therapy are summarized under functional, immunological aspects. An actual overview of the antitumor prosperity of all genetically engineered tumor cells expressing recombinant cytokines which were characterized by animal experiments is given. The application of antigen-presenting cells which are triple transgenic for immune stimulatory cytokines, tumor specific antigens, and the correlated major histocompatibility complex class I necessary for tumor antigen presentation is explained exemplarily. A recent experimental animal model characterizing critical parameters for preconditioning the host prior to ACT of transgenic T cells and essential therapeutic conditions is described.
000829378 536__ $$0G:(DE-HGF)POF3-899$$a899 - ohne Topic (POF3-899)$$cPOF3-899$$fPOF III$$x0
000829378 588__ $$aDataset connected to CrossRef Book Series
000829378 7001_ $$0P:(DE-HGF)0$$aBonavida, Benjamin$$b1$$eEditor
000829378 7001_ $$0P:(DE-HGF)0$$aBette, Michael$$b2
000829378 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b3
000829378 7001_ $$0P:(DE-HGF)0$$aBarth, Stephen$$b4$$eCorresponding author
000829378 773__ $$a10.1007/978-3-319-17275-0_9
000829378 909CO $$ooai:juser.fz-juelich.de:829378$$pVDB
000829378 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)145614$$aForschungszentrum Jülich$$b3$$kFZJ
000829378 9131_ $$0G:(DE-HGF)POF3-899$$1G:(DE-HGF)POF3-890$$2G:(DE-HGF)POF3-800$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000829378 920__ $$lyes
000829378 9201_ $$0I:(DE-Juel1)GRS-20100316$$kGRS Jülich ; German Research School for Simulation Sciences$$lGRS$$x0
000829378 980__ $$acontb
000829378 980__ $$aVDB
000829378 980__ $$aI:(DE-Juel1)GRS-20100316
000829378 980__ $$aUNRESTRICTED