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@INBOOK{Verma:829378,
      author       = {Bette, Michael and Carloni, Paolo and Barth, Stephen},
      editor       = {Verma, Rama Shanker and Bonavida, Benjamin},
      title        = {{T}herapeutic {I}mpact of {I}mmune {R}esponses in {C}ancer},
      volume       = {6},
      address      = {Cham},
      publisher    = {Springer International Publishing},
      reportid     = {FZJ-2017-03091},
      isbn         = {978-3-319-17274-3 (print)},
      series       = {Resistance to Targeted Anti-Cancer Therapeutics},
      pages        = {221 - 245},
      year         = {2015},
      comment      = {Resistance to Immunotoxins in Cancer Therapy / Verma, Rama
                      Shanker (Editor) ; Cham : Springer International Publishing,
                      2015, Chapter 9 ; ISSN: 2196-5501=2196-551X ; ISBN:
                      978-3-319-17274-3=978-3-319-17275-0 ;
                      doi:10.1007/978-3-319-17275-0},
      booktitle     = {Resistance to Immunotoxins in Cancer
                       Therapy / Verma, Rama Shanker (Editor)
                       ; Cham : Springer International
                       Publishing, 2015, Chapter 9 ; ISSN:
                       2196-5501=2196-551X ; ISBN:
                       978-3-319-17274-3=978-3-319-17275-0 ;
                       doi:10.1007/978-3-319-17275-0},
      abstract     = {Therapeutic targeted oncoimmunology has a long history
                      reaching back to the nineteenth century and represents the
                      basis of modern tumor immunology. Cell biological and
                      molecular genetic techniques have uncovered crucial cellular
                      and molecular mechanisms underlying effective cancer
                      immunotherapies used in the clinic. To illustrate the
                      scientific way that led to actual insights into the
                      molecular and cellular approaches realized in recent cancer
                      therapies, this chapter introduces into the history of
                      oncoimmunology. Experimental findings of adoptive cell
                      transfer-based cancer therapy are summarized under
                      functional, immunological aspects. An actual overview of the
                      antitumor prosperity of all genetically engineered tumor
                      cells expressing recombinant cytokines which were
                      characterized by animal experiments is given. The
                      application of antigen-presenting cells which are triple
                      transgenic for immune stimulatory cytokines, tumor specific
                      antigens, and the correlated major histocompatibility
                      complex class I necessary for tumor antigen presentation is
                      explained exemplarily. A recent experimental animal model
                      characterizing critical parameters for preconditioning the
                      host prior to ACT of transgenic T cells and essential
                      therapeutic conditions is described.},
      cin          = {GRS Jülich ; German Research School for Simulation
                      Sciences},
      cid          = {I:(DE-Juel1)GRS-20100316},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)7},
      UT           = {WOS:000365949800010},
      doi          = {10.1007/978-3-319-17275-0_9},
      url          = {https://juser.fz-juelich.de/record/829378},
}