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@ARTICLE{Palermo:829379,
      author       = {Palermo, Giulia and Minniti, Elirosa and Greco, Maria Laura
                      and Riccardi, Laura and Simoni, Elena and Convertino, Marino
                      and Marchetti, Chiara and Rosini, Michela and Sissi, Claudia
                      and Minarini, Anna and De Vivo, Marco},
      title        = {{A}n optimized polyamine moiety boosts the potency of human
                      type {II} topoisomerase poisons as quantified by comparative
                      analysis centered on the clinical candidate {F}14512},
      journal      = {Chemical communications},
      volume       = {51},
      number       = {76},
      issn         = {1364-548X},
      address      = {Cambridge},
      publisher    = {Soc.},
      reportid     = {FZJ-2017-03092},
      pages        = {14310 - 14313},
      year         = {2015},
      abstract     = {Combined computational–experimental analyses explain and
                      quantify the spermine-vectorized F14512's boosted potency as
                      a topoII poison. We found that an optimized polyamine moiety
                      boosts drug binding to the topoII/DNA cleavage complex,
                      rather than to the DNA alone. These results provide new
                      structural bases and key reference data for designing new
                      human topoII poisons.},
      cin          = {IAS-5 / INM-9},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000361073400005},
      pubmed       = {pmid:26234198},
      doi          = {10.1039/C5CC05065K},
      url          = {https://juser.fz-juelich.de/record/829379},
}