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| 245 | _ | _ | |a An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512 |
| 260 | _ | _ | |a Cambridge |c 2015 |b Soc. |
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| 520 | _ | _ | |a Combined computational–experimental analyses explain and quantify the spermine-vectorized F14512's boosted potency as a topoII poison. We found that an optimized polyamine moiety boosts drug binding to the topoII/DNA cleavage complex, rather than to the DNA alone. These results provide new structural bases and key reference data for designing new human topoII poisons. |
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| 700 | 1 | _ | |a Minniti, Elirosa |0 P:(DE-HGF)0 |b 1 |
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| 700 | 1 | _ | |a Minarini, Anna |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a De Vivo, Marco |0 P:(DE-Juel1)167585 |b 10 |e Corresponding author |
| 773 | _ | _ | |a 10.1039/C5CC05065K |g Vol. 51, no. 76, p. 14310 - 14313 |0 PERI:(DE-600)1472881-3 |n 76 |p 14310 - 14313 |t Chemical communications |v 51 |y 2015 |x 1364-548X |
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