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@ARTICLE{Kemmerling:829414,
      author       = {Kemmerling, Nadja and Wunderlich, Patrick and Theil, Sandra
                      and Linnartz-Gerlach, Bettina and Hersch, Nils and Hoffmann,
                      Bernd and Heneka, Michael T. and de Strooper, Bart and
                      Neumann, Harald and Walter, Jochen},
      title        = {{I}ntramembranous processing by γ-secretase regulates
                      reverse signaling of ephrin-{B}2 in migration of microglia},
      journal      = {Glia},
      volume       = {65},
      number       = {7},
      issn         = {0894-1491},
      address      = {Bognor Regis [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2017-03118},
      pages        = {1103–1118},
      year         = {2017},
      abstract     = {The Eph-ephrin system plays pivotal roles in cell adhesion
                      and migration. The receptor-like functions of the ephrin
                      ligands allow the regulation of intracellular processes via
                      reverse signaling. γ-Secretase mediated processing of
                      ephrin-B has previously been linked to activation of Src, a
                      kinase crucial for focal adhesion and podosome
                      phosphorylation. Here, we analyzed the role of γ-secretase
                      in the stimulation of reverse ephrin-B2 signaling in the
                      migration of mouse embryonic stem cell derived microglia.
                      The proteolytic generation of the ephrin-B2 intracellular
                      domain (ICD) by γ-secretase stimulates Src and focal
                      adhesion kinase (FAK). Inhibition of γ-secretase decreased
                      the phosphorylation of Src and FAK, and reduced cell
                      motility. These effects were associated with enlargement of
                      the podosomal surface. Interestingly, expression of
                      ephrin-B2 ICD could rescue these effects, indicating that
                      this proteolytic fragment mediates the activation of Src and
                      FAK, and thereby regulates podosomal dynamics in microglial
                      cells. Together, these results identify γ-secretase as well
                      as ephrin-B2 as regulators of microglial migration.},
      cin          = {ICS-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-7-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000401345400007},
      pubmed       = {pmid:28370426},
      doi          = {10.1002/glia.23147},
      url          = {https://juser.fz-juelich.de/record/829414},
}