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| Home > Publications database > Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia > print |
| 001 | 829414 | ||
| 005 | 20210129230301.0 | ||
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| 100 | 1 | _ | |a Kemmerling, Nadja |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia |
| 260 | _ | _ | |a Bognor Regis [u.a.] |c 2017 |b Wiley-Liss |
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| 520 | _ | _ | |a The Eph-ephrin system plays pivotal roles in cell adhesion and migration. The receptor-like functions of the ephrin ligands allow the regulation of intracellular processes via reverse signaling. γ-Secretase mediated processing of ephrin-B has previously been linked to activation of Src, a kinase crucial for focal adhesion and podosome phosphorylation. Here, we analyzed the role of γ-secretase in the stimulation of reverse ephrin-B2 signaling in the migration of mouse embryonic stem cell derived microglia. The proteolytic generation of the ephrin-B2 intracellular domain (ICD) by γ-secretase stimulates Src and focal adhesion kinase (FAK). Inhibition of γ-secretase decreased the phosphorylation of Src and FAK, and reduced cell motility. These effects were associated with enlargement of the podosomal surface. Interestingly, expression of ephrin-B2 ICD could rescue these effects, indicating that this proteolytic fragment mediates the activation of Src and FAK, and thereby regulates podosomal dynamics in microglial cells. Together, these results identify γ-secretase as well as ephrin-B2 as regulators of microglial migration. |
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| 700 | 1 | _ | |a Neumann, Harald |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Walter, Jochen |0 P:(DE-HGF)0 |b 9 |e Corresponding author |
| 773 | _ | _ | |a 10.1002/glia.23147 |0 PERI:(DE-600)1474828-9 |n 7 |p 1103–1118 |t Glia |v 65 |y 2017 |x 0894-1491 |
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