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@ARTICLE{Langen:829452,
      author       = {Langen, Karl-Josef and Galldiks, Norbert and Hattingen,
                      Elke and Shah, N. J.},
      title        = {{A}dvances in neuro-oncology imaging},
      journal      = {Nature reviews / Neurology},
      volume       = {13},
      number       = {5},
      issn         = {1759-4766},
      address      = {New York, NY},
      publisher    = {Nature Publ. Group},
      reportid     = {FZJ-2017-03151},
      pages        = {279-289},
      year         = {2017},
      abstract     = {Despite the fact that MRI has evolved to become the
                      standard method for diagnosis and monitoring of patients
                      with brain tumours, conventional MRI sequences have two key
                      limitations: the inability to show the full extent of the
                      tumour and the inability to differentiate neoplastic tissue
                      from nonspecific, treatment-related changes after surgery,
                      radiotherapy, chemotherapy or immunotherapy. In the past
                      decade, PET involving the use of radiolabelled amino acids
                      has developed into an important diagnostic tool to overcome
                      some of the shortcomings of conventional MRI. The Response
                      Assessment in Neuro-Oncology working group — an
                      international effort to develop new standardized response
                      criteria for clinical trials in brain tumours — has
                      recommended the additional use of amino acid PET imaging for
                      brain tumour management. Concurrently, a number of advanced
                      MRI techniques such as magnetic resonance spectroscopic
                      imaging and perfusion weighted imaging are under clinical
                      evaluation to target the same diagnostic problems. This
                      Review summarizes the clinical role of amino acid PET in
                      relation to advanced MRI techniques for differential
                      diagnosis of brain tumours; delineation of tumour extent for
                      treatment planning and biopsy guidance; post-treatment
                      differentiation between tumour progression or recurrence
                      versus treatment-related changes; and monitoring response to
                      therapy. An outlook for future developments in PET and MRI
                      techniques is also presented.},
      cin          = {INM-3 / INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000400369800004},
      pubmed       = {pmid:28387340},
      doi          = {10.1038/nrneurol.2017.44},
      url          = {https://juser.fz-juelich.de/record/829452},
}