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000829625 1001_ $$0P:(DE-Juel1)161334$$aZeineh, Michael$$b0$$eCorresponding author
000829625 245__ $$aDirect Visualization and Mapping of the Spatial Course of Fiber Tracts at Microscopic Resolution in the Human Hippocampus
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000829625 520__ $$aWhile hippocampal connectivity is essential to normal memory function, our knowledge of human hippocampal circuitry is largely inferred from animal studies. Using polarized light microscopy at 1.3 µm resolution, we have directly visualized the 3D course of key medial temporal pathways in 3 ex vivo human hemispheres and 2 ex vivo vervet monkey hemispheres. The multiple components of the perforant path system were clearly identified: Superficial sheets of fibers emanating from the entorhinal cortex project to the presubiculum and parasubiculum, intermixed transverse and longitudinal angular bundle fibers perforate the subiculum and then project to the cornu ammonis (CA) fields and dentate molecular layer, and a significant alvear component runs from the angular bundle to the CA fields. From the hilus, mossy fibers localize to regions of high kainate receptor density, and the endfolial pathway, mostly investigated in humans, merges with the Schaffer collaterals. This work defines human hippocampal pathways underlying mnemonic function at an unprecedented resolution.
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000829625 536__ $$0G:(DE-Juel1)NIH-R01MH092311$$aNIH-R01MH092311 - Postnatal Development of Cortical Receptors and White Matter Tracts in the Vervet (NIH-R01MH092311)$$cNIH-R01MH092311$$fPostnatal Development of Cortical Receptors and White Matter Tracts in the Vervet$$x3
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000829625 7001_ $$0P:(DE-HGF)0$$aGräβel, David$$b3
000829625 7001_ $$0P:(DE-HGF)0$$aGoubran, Maged$$b4
000829625 7001_ $$0P:(DE-HGF)0$$aWree, Andreas$$b5
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000829625 7001_ $$0P:(DE-Juel1)131714$$aZilles, Karl$$b8$$ufzj
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