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@ARTICLE{Zeineh:829625,
      author       = {Zeineh, Michael and Palomero-Gallagher, Nicola and Axer,
                      Markus and Gräβel, David and Goubran, Maged and Wree,
                      Andreas and Woods, Roger and Amunts, Katrin and Zilles,
                      Karl},
      title        = {{D}irect {V}isualization and {M}apping of the {S}patial
                      {C}ourse of {F}iber {T}racts at {M}icroscopic {R}esolution
                      in the {H}uman {H}ippocampus},
      journal      = {Cerebral cortex},
      volume       = {27},
      number       = {3},
      issn         = {1460-2199},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2017-03294},
      pages        = {1779-1794},
      year         = {2017},
      abstract     = {While hippocampal connectivity is essential to normal
                      memory function, our knowledge of human hippocampal
                      circuitry is largely inferred from animal studies. Using
                      polarized light microscopy at 1.3 µm resolution, we have
                      directly visualized the 3D course of key medial temporal
                      pathways in 3 ex vivo human hemispheres and 2 ex vivo vervet
                      monkey hemispheres. The multiple components of the perforant
                      path system were clearly identified: Superficial sheets of
                      fibers emanating from the entorhinal cortex project to the
                      presubiculum and parasubiculum, intermixed transverse and
                      longitudinal angular bundle fibers perforate the subiculum
                      and then project to the cornu ammonis (CA) fields and
                      dentate molecular layer, and a significant alvear component
                      runs from the angular bundle to the CA fields. From the
                      hilus, mossy fibers localize to regions of high kainate
                      receptor density, and the endfolial pathway, mostly
                      investigated in humans, merges with the Schaffer
                      collaterals. This work defines human hippocampal pathways
                      underlying mnemonic function at an unprecedented
                      resolution.},
      cin          = {INM-1 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {571 - Connectivity and Activity (POF3-571) / HBP SGA1 -
                      Human Brain Project Specific Grant Agreement 1 (720270) /
                      SMHB - Supercomputing and Modelling for the Human Brain
                      (HGF-SMHB-2013-2017) / NIH-R01MH092311 - Postnatal
                      Development of Cortical Receptors and White Matter Tracts in
                      the Vervet (NIH-R01MH092311)},
      pid          = {G:(DE-HGF)POF3-571 / G:(EU-Grant)720270 /
                      G:(DE-Juel1)HGF-SMHB-2013-2017 /
                      G:(DE-Juel1)NIH-R01MH092311},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000397636600007},
      pubmed       = {pmid:26874183},
      doi          = {10.1093/cercor/bhw010},
      url          = {https://juser.fz-juelich.de/record/829625},
}