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@ARTICLE{Mauer:829814,
author = {Mauer, Johannes and Peltomäki, Matti and Poblete, Simón
and Gompper, Gerhard and Fedosov, Dmitry A.},
title = {{S}tatic and dynamic light scattering by red blood cells:
{A} numerical study},
journal = {PLoS one},
volume = {12},
number = {5},
issn = {1932-6203},
address = {Lawrence, Kan.},
publisher = {PLoS},
reportid = {FZJ-2017-03442},
pages = {e0176799},
year = {2017},
abstract = {Light scattering is a well-established experimental
technique, which gains more and more popularity in the
biological field because it offers the means for
non-invasive imaging and detection. However, the
interpretation of light-scattering signals remains
challenging due to the complexity of most biological
systems. Here, we investigate static and dynamic scattering
properties of red blood cells (RBCs) using two mesoscopic
hydrodynamics simulation methods—multi-particle collision
dynamics and dissipative particle dynamics. Light scattering
is studied for various membrane shear elasticities, bending
rigidities, and RBC shapes (e.g., biconcave and
stomatocyte). Simulation results from the two simulation
methods show good agreement, and demonstrate that the static
light scattering of a diffusing RBC is not very sensitive to
the changes in membrane properties and moderate alterations
in cell shapes. We also compute dynamic light scattering of
a diffusing RBC, from which dynamic properties of RBCs such
as diffusion coefficients can be accessed. In contrast to
static light scattering, the dynamic measurements can be
employed to differentiate between the biconcave and
stomatocytic RBC shapes and generally allow the
differentiation based on the membrane properties. Our
simulation results can be used for better understanding of
light scattering by RBCs and the development of new
non-invasive methods for blood-flow monitoring.},
cin = {IAS-2 / JARA-HPC},
ddc = {500},
cid = {I:(DE-Juel1)IAS-2-20090406 / $I:(DE-82)080012_20140620$},
pnm = {553 - Physical Basis of Diseases (POF3-553) / Blood Flow
Resistance in Microvascular Networks $(jics21_20131101)$},
pid = {G:(DE-HGF)POF3-553 / $G:(DE-Juel1)jics21_20131101$},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000400648500073},
doi = {10.1371/journal.pone.0176799},
url = {https://juser.fz-juelich.de/record/829814},
}