000829843 001__ 829843
000829843 005__ 20240712100829.0
000829843 0247_ $$2doi$$a10.1371/journal.pone.0172673
000829843 0247_ $$2Handle$$a2128/14357
000829843 0247_ $$2WOS$$aWOS:000394688200110
000829843 0247_ $$2altmetric$$aaltmetric:21833744
000829843 0247_ $$2pmid$$a28234973
000829843 037__ $$aFZJ-2017-03465
000829843 082__ $$a500
000829843 1001_ $$0P:(DE-Juel1)165935$$aPoshyvailo, Liubov$$b0
000829843 245__ $$aDoes metabolite channeling accelerate enzyme-catalyzed cascade reactions?
000829843 260__ $$aLawrence, Kan.$$bPLoS$$c2017
000829843 3367_ $$2DRIVER$$aarticle
000829843 3367_ $$2DataCite$$aOutput Types/Journal article
000829843 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1517900145_9649
000829843 3367_ $$2BibTeX$$aARTICLE
000829843 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000829843 3367_ $$00$$2EndNote$$aJournal Article
000829843 520__ $$aMetabolite or substrate channeling is a direct transfer of metabolites from one enzyme to the next enzyme in a cascade. Among many potential advantages of substrate channeling, acceleration of the total reaction rate is considered as one of the most important and self-evident. However, using a simple model, supported by stochastic simulations, we show that it is not always the case; particularly at long times (i.e. in steady state) and high substrate concentrations, a channeled reaction cannot be faster, and can even be slower, than the original non-channeled cascade reaction. In addition we show that increasing the degree of channeling may lead to an increase of the metabolite pool size. We substantiate that the main advantage of channeling likely lies in protecting metabolites from degradation or competing side reactions.
000829843 536__ $$0G:(DE-HGF)POF3-583$$a583 - Innovative Synergisms (POF3-583)$$cPOF3-583$$fPOF III$$x0
000829843 536__ $$0G:(DE-Juel1)HITEC-20170406$$aHITEC - Helmholtz Interdisciplinary Doctoral Training in Energy and Climate Research (HITEC) (HITEC-20170406)$$cHITEC-20170406$$x1
000829843 588__ $$aDataset connected to CrossRef
000829843 7001_ $$0P:(DE-Juel1)129081$$avon Lieres, Eric$$b1
000829843 7001_ $$0P:(DE-Juel1)159264$$aKondrat, Svyatoslav$$b2$$eCorresponding author
000829843 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0172673$$gVol. 12, no. 2, p. e0172673 -$$n2$$pe0172673 -$$tPLoS one$$v12$$x1932-6203$$y2017
000829843 8564_ $$uhttps://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.pdf$$yOpenAccess
000829843 8564_ $$uhttps://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.gif?subformat=icon$$xicon$$yOpenAccess
000829843 8564_ $$uhttps://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
000829843 8564_ $$uhttps://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
000829843 8564_ $$uhttps://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
000829843 8564_ $$uhttps://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000829843 8767_ $$92017-02-15$$d2017-02-20$$eAPC$$jZahlung erfolgt$$zehem. Mitarbeiter; PONE-D-16-37293, USD 1.495,-; Gebühren in JuSER
000829843 909CO $$ooai:juser.fz-juelich.de:829843$$pdnbdelivery$$popenCost$$pVDB$$pdriver$$pOpenAPC$$popen_access$$popenaire
000829843 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)165935$$aForschungszentrum Jülich$$b0$$kFZJ
000829843 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)129081$$aForschungszentrum Jülich$$b1$$kFZJ
000829843 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)159264$$aForschungszentrum Jülich$$b2$$kFZJ
000829843 9131_ $$0G:(DE-HGF)POF3-583$$1G:(DE-HGF)POF3-580$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lKey Technologies for the Bioeconomy$$vInnovative Synergisms$$x0
000829843 9141_ $$y2017
000829843 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000829843 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000829843 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000829843 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000829843 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000829843 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPLOS ONE : 2015
000829843 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000829843 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000829843 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000829843 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000829843 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000829843 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000829843 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000829843 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000829843 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000829843 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000829843 9201_ $$0I:(DE-Juel1)IEK-7-20101013$$kIEK-7$$lStratosphäre$$x0
000829843 9201_ $$0I:(DE-Juel1)IBG-1-20101118$$kIBG-1$$lBiotechnologie$$x1
000829843 9801_ $$aFullTexts
000829843 980__ $$ajournal
000829843 980__ $$aVDB
000829843 980__ $$aI:(DE-Juel1)IEK-7-20101013
000829843 980__ $$aI:(DE-Juel1)IBG-1-20101118
000829843 980__ $$aUNRESTRICTED
000829843 980__ $$aAPC
000829843 981__ $$aI:(DE-Juel1)ICE-4-20101013