TY  - JOUR
AU  - Poshyvailo, Liubov
AU  - von Lieres, Eric
AU  - Kondrat, Svyatoslav
TI  - Does metabolite channeling accelerate enzyme-catalyzed cascade reactions?
JO  - PLoS one
VL  - 12
IS  - 2
SN  - 1932-6203
CY  - Lawrence, Kan.
PB  - PLoS
M1  - FZJ-2017-03465
SP  - e0172673 -
PY  - 2017
AB  - Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to the next enzyme in a cascade. Among many potential advantages of substrate channeling, acceleration of the total reaction rate is considered as one of the most important and self-evident. However, using a simple model, supported by stochastic simulations, we show that it is not always the case; particularly at long times (i.e. in steady state) and high substrate concentrations, a channeled reaction cannot be faster, and can even be slower, than the original non-channeled cascade reaction. In addition we show that increasing the degree of channeling may lead to an increase of the metabolite pool size. We substantiate that the main advantage of channeling likely lies in protecting metabolites from degradation or competing side reactions.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000394688200110
C6  - 28234973
DO  - DOI:10.1371/journal.pone.0172673
UR  - https://juser.fz-juelich.de/record/829843
ER  -