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@ARTICLE{Poshyvailo:829843,
      author       = {Poshyvailo, Liubov and von Lieres, Eric and Kondrat,
                      Svyatoslav},
      title        = {{D}oes metabolite channeling accelerate enzyme-catalyzed
                      cascade reactions?},
      journal      = {PLoS one},
      volume       = {12},
      number       = {2},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {FZJ-2017-03465},
      pages        = {e0172673 -},
      year         = {2017},
      abstract     = {Metabolite or substrate channeling is a direct transfer of
                      metabolites from one enzyme to the next enzyme in a cascade.
                      Among many potential advantages of substrate channeling,
                      acceleration of the total reaction rate is considered as one
                      of the most important and self-evident. However, using a
                      simple model, supported by stochastic simulations, we show
                      that it is not always the case; particularly at long times
                      (i.e. in steady state) and high substrate concentrations, a
                      channeled reaction cannot be faster, and can even be slower,
                      than the original non-channeled cascade reaction. In
                      addition we show that increasing the degree of channeling
                      may lead to an increase of the metabolite pool size. We
                      substantiate that the main advantage of channeling likely
                      lies in protecting metabolites from degradation or competing
                      side reactions.},
      cin          = {IEK-7 / IBG-1},
      ddc          = {500},
      cid          = {I:(DE-Juel1)IEK-7-20101013 / I:(DE-Juel1)IBG-1-20101118},
      pnm          = {583 - Innovative Synergisms (POF3-583) / HITEC - Helmholtz
                      Interdisciplinary Doctoral Training in Energy and Climate
                      Research (HITEC) (HITEC-20170406)},
      pid          = {G:(DE-HGF)POF3-583 / G:(DE-Juel1)HITEC-20170406},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000394688200110},
      pubmed       = {28234973},
      doi          = {10.1371/journal.pone.0172673},
      url          = {https://juser.fz-juelich.de/record/829843},
}