Gast ::
| Hauptseite > Publikationsdatenbank > Does metabolite channeling accelerate enzyme-catalyzed cascade reactions? > print |
| Hauptseite > Publikationsdatenbank > Does metabolite channeling accelerate enzyme-catalyzed cascade reactions? > print |
| 001 | 829843 | ||
| 005 | 20240712100829.0 | ||
| 024 | 7 | _ | |a 10.1371/journal.pone.0172673 |2 doi |
| 024 | 7 | _ | |a 2128/14357 |2 Handle |
| 024 | 7 | _ | |a WOS:000394688200110 |2 WOS |
| 024 | 7 | _ | |a altmetric:21833744 |2 altmetric |
| 024 | 7 | _ | |a 28234973 |2 pmid |
| 037 | _ | _ | |a FZJ-2017-03465 |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Poshyvailo, Liubov |0 P:(DE-Juel1)165935 |b 0 |
| 245 | _ | _ | |a Does metabolite channeling accelerate enzyme-catalyzed cascade reactions? |
| 260 | _ | _ | |a Lawrence, Kan. |c 2017 |b PLoS |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1517900145_9649 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to the next enzyme in a cascade. Among many potential advantages of substrate channeling, acceleration of the total reaction rate is considered as one of the most important and self-evident. However, using a simple model, supported by stochastic simulations, we show that it is not always the case; particularly at long times (i.e. in steady state) and high substrate concentrations, a channeled reaction cannot be faster, and can even be slower, than the original non-channeled cascade reaction. In addition we show that increasing the degree of channeling may lead to an increase of the metabolite pool size. We substantiate that the main advantage of channeling likely lies in protecting metabolites from degradation or competing side reactions. |
| 536 | _ | _ | |a 583 - Innovative Synergisms (POF3-583) |0 G:(DE-HGF)POF3-583 |c POF3-583 |f POF III |x 0 |
| 536 | _ | _ | |0 G:(DE-Juel1)HITEC-20170406 |x 1 |c HITEC-20170406 |a HITEC - Helmholtz Interdisciplinary Doctoral Training in Energy and Climate Research (HITEC) (HITEC-20170406) |
| 588 | _ | _ | |a Dataset connected to CrossRef |
| 700 | 1 | _ | |a von Lieres, Eric |0 P:(DE-Juel1)129081 |b 1 |
| 700 | 1 | _ | |a Kondrat, Svyatoslav |0 P:(DE-Juel1)159264 |b 2 |e Corresponding author |
| 773 | _ | _ | |a 10.1371/journal.pone.0172673 |g Vol. 12, no. 2, p. e0172673 - |0 PERI:(DE-600)2267670-3 |n 2 |p e0172673 - |t PLoS one |v 12 |y 2017 |x 1932-6203 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.pdf |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.gif?subformat=icon |x icon |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.jpg?subformat=icon-1440 |x icon-1440 |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.jpg?subformat=icon-180 |x icon-180 |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.jpg?subformat=icon-640 |x icon-640 |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/829843/files/journal.pone.0172673.pdf?subformat=pdfa |x pdfa |y OpenAccess |
| 909 | C | O | |o oai:juser.fz-juelich.de:829843 |p openaire |p open_access |p OpenAPC |p driver |p VDB |p openCost |p dnbdelivery |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-Juel1)165935 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)129081 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 2 |6 P:(DE-Juel1)159264 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Key Technologies for the Bioeconomy |1 G:(DE-HGF)POF3-580 |0 G:(DE-HGF)POF3-583 |2 G:(DE-HGF)POF3-500 |v Innovative Synergisms |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b PLOS ONE : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 920 | 1 | _ | |0 I:(DE-Juel1)IEK-7-20101013 |k IEK-7 |l Stratosphäre |x 0 |
| 920 | 1 | _ | |0 I:(DE-Juel1)IBG-1-20101118 |k IBG-1 |l Biotechnologie |x 1 |
| 980 | 1 | _ | |a FullTexts |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)IEK-7-20101013 |
| 980 | _ | _ | |a I:(DE-Juel1)IBG-1-20101118 |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a APC |
| 981 | _ | _ | |a I:(DE-Juel1)ICE-4-20101013 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|