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000830009 1001_ $$0P:(DE-HGF)0$$aGiani, M.$$b0
000830009 245__ $$aEarly stages of clathrin aggregation at a membrane in coarse-grained simulations
000830009 260__ $$aMelville, NY$$bAmerican Institute of Physics$$c2017
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000830009 520__ $$aThe self-assembly process of clathrin coated pits during endocytosis has been simulated by combining and extending coarse grained models of the clathrin triskelion, the adaptor protein AP2, and a flexible network membrane. The AP2’s core, upon binding to membrane and cargo, releases a motif that can bind clathrin. In conditions where the core-membrane-cargo binding is weak, the binding of this motif to clathrin can result in a stable complex. We characterize the conditions and mechanisms resulting in the formation of clathrin lattices that curve the membrane, i.e., clathrin coated pits. The mechanical properties of the AP2 β linker appear crucial to the orientation of the curved clathrin lattice relative to the membrane, with wild-type short linkers giving rise to the inward curving buds enabling endocytosis while long linkers produce upside-down cages and outward curving bulges
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000830009 7001_ $$0P:(DE-HGF)0$$aden Otter, W. K.$$b1$$eCorresponding author
000830009 7001_ $$0P:(DE-Juel1)159317$$aBriels, Willem$$b2$$ufzj
000830009 773__ $$0PERI:(DE-600)1473050-9$$a10.1063/1.4979985$$gVol. 146, no. 15, p. 155102 -$$n15$$p155102 -$$tThe journal of chemical physics$$v146$$x1089-7690$$y2017
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