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@ARTICLE{Giani:830009,
      author       = {Giani, M. and den Otter, W. K. and Briels, Willem},
      title        = {{E}arly stages of clathrin aggregation at a membrane in
                      coarse-grained simulations},
      journal      = {The journal of chemical physics},
      volume       = {146},
      number       = {15},
      issn         = {1089-7690},
      address      = {Melville, NY},
      publisher    = {American Institute of Physics},
      reportid     = {FZJ-2017-03611},
      pages        = {155102 -},
      year         = {2017},
      abstract     = {The self-assembly process of clathrin coated pits during
                      endocytosis has been simulated by combining and extending
                      coarse grained models of the clathrin triskelion, the
                      adaptor protein AP2, and a flexible network membrane. The
                      AP2’s core, upon binding to membrane and cargo, releases a
                      motif that can bind clathrin. In conditions where the
                      core-membrane-cargo binding is weak, the binding of this
                      motif to clathrin can result in a stable complex. We
                      characterize the conditions and mechanisms resulting in the
                      formation of clathrin lattices that curve the membrane,
                      i.e., clathrin coated pits. The mechanical properties of the
                      AP2 β linker appear crucial to the orientation of the
                      curved clathrin lattice relative to the membrane, with
                      wild-type short linkers giving rise to the inward curving
                      buds enabling endocytosis while long linkers produce
                      upside-down cages and outward curving bulges},
      cin          = {ICS-3},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-3-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000399904500036},
      doi          = {10.1063/1.4979985},
      url          = {https://juser.fz-juelich.de/record/830009},
}