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000830124 005__ 20240619091226.0
000830124 0247_ $$2Handle$$a2128/15922
000830124 0247_ $$2URN$$aurn:nbn:de:0001-2017121302
000830124 0247_ $$2ISSN$$a1866-1807
000830124 020__ $$a978-3-95806-265-8
000830124 037__ $$aFZJ-2017-03703
000830124 1001_ $$0P:(DE-Juel1)159559$$aKireev, Dmitry$$b0$$eCorresponding author$$gmale$$ufzj
000830124 245__ $$aGraphene Devices for Extracellular Measurements$$f- 2017-03-31
000830124 260__ $$aJülich$$bForschungszentrum Jülich GmbH Zentralbibliothek, Verlag$$c2017
000830124 300__ $$aIX, 169 S.
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000830124 3367_ $$0PUB:(DE-HGF)11$$2PUB:(DE-HGF)$$aDissertation / PhD Thesis$$bphd$$mphd$$s1511277299_23755
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000830124 4900_ $$aSchriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies$$v155
000830124 502__ $$aRWTH Aachen, Diss., 2017$$bDr.$$cRWTH Aachen$$d2017
000830124 520__ $$aRecording extracellular potentials from electrogenic cells (especially neurons) is the hallmark destination of modern bioelectronics. Graphene is a promising material, which possesses features relevant to bioelectronics applications. Graphene-based electrode arrays (GMEAs) and more complicated graphene field effect transistors (GFETs) comprise a new type of bioelectronic device application. Biocompatibility, stability, excellent and unique electronic properties, scalability, and pure two-dimensional structure make graphene the perfect material for bioelectronic applications. The advantages of graphene as part of such devices are numerous: from a general  exibility and biocompatibility to the unique electronic properties of graphene. In this work, the GMEAs and GFETs are fabricated using CVD-grown graphene and a scalable cleanroom-based technology. The devices are fabricated on both rigid and  exible substrates. In order to ensure a wafer-scale fabrication of the devices, a new high throughput graphene transfer technique is established. The technique allows me to use just 4 cm$^{2}$ of CVD-grown graphene to fabricate a whole 4-inch wafer with 52 chips on it. Rigid GFETs, fabricated on different substrates, with a variety of channel geometries (width/length), reveal a linear relation between the transconductance and the width/length ratio. The area normalized electrolyte-gated transconductance is in the range of 1-2 mS V$^{−1}$ $\Box$, and does not strongly depend on the substrate. Influence of the ionic strength on the transistor performance is investigated as a part of the work. Double contacts are found to decrease the effective resistance and the transfer length, but do not improve the transconductance. An electrochemical annealing/cleaning effect is investigated and proposed to originate from the out-of-plane gate leakage current. The devices are used as a proof-of-concept for bioelectronic sensors, recording external potentials from $\textit{ex vivo}$ heart tissue and $\textit{in vitro}$ cardiomyocyte-like cells (HL-1). Via multichannel measurements we are able to record and analyze both difference in action potentials as well as their spatial propagation through the chip. The recordings show distinguishable action potentials with a signal to noise ratio over 14 from $\textit{ex vivo}$ tissue and over 6 from the cardiac-like cell line $\textit{in vitro}$. Furthermore, I accomplished $\textit{in vitro}$ recordings of neuronal signals with a distinguishable bursting activity for the first time. [...]
000830124 536__ $$0G:(DE-HGF)POF3-552$$a552 - Engineering Cell Function (POF3-552)$$cPOF3-552$$fPOF III$$x0
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000830124 9141_ $$y2017
000830124 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)159559$$aForschungszentrum Jülich$$b0$$kFZJ
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