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@INPROCEEDINGS{Niether:830383,
      author       = {Niether, Doreen and Kawaguchi, Tsubasa and Hovancova, Jana
                      and Eguchi, Kazuja and Dhont, Jan K.G. and Kita, Rio and
                      Wiegand, Simone},
      title        = {{T}hermophoresis of cyclodextrins and
                      cyclodextrin-drug-complexes},
      reportid     = {FZJ-2017-03936},
      year         = {2017},
      abstract     = {The behaviour of biomolecules in a temperature gradient,
                      known as thermodiffusion, changes when a ligand binds. In
                      recent years, this effect has been used to gain detailed
                      information on binding dynamics, although the
                      physicochemical processes are still unclear [1]. We focused
                      on the question how the hydration layer affects
                      thermodiffusion when it changes due to complex formation. As
                      model system we used cyclodextrin complexes with
                      acetylsalicylic acid (Aspirin). Cyclodextrins are cyclic
                      oligosaccharides that show a strong tendency towards complex
                      formation. For that reason they are interesting as drug
                      delivery systems [2,3.] The thermodiffusion of different
                      cyclodextrins [4] and their aspirin complexes was
                      investigated in a temperature range from 10 to 50°C by
                      infrared thermal diffusion forced Rayleigh scattering
                      (IR-TDFRS). Additionally, NMR measurements were performed at
                      25 and 60°C to obtain information about stability and
                      structure of the complexes. We found that all cyclodextrins
                      show a stronger diffusion towards the cold side when Aspirin
                      binds. This behaviour suggests a weaker interaction with the
                      surrounding water that could be explained by hydrogen bond
                      formation inside the complex.[1] M. Jerabek-Willemsen, T.
                      André, W. Wanner, H. Roth, S. Duhr, P. Baaske, and D.
                      Breitsprecher, J. Mol. Struct. (2014).[2] E. Del Valle,
                      Process Biochemistry 39, 1033 (2004).[3] J. Szejtli, Drug
                      Invest. 2, 11 (1990).[4] K. Eguchi, D. Niether, S. Wiegand,
                      and R. Kita, Eur.Phys. J. E 39, 16086 (2016).},
      month         = {May},
      date          = {2017-05-25},
      organization  = {116th General Assembly of the German
                       Bunsen Society for Physical Chemistry,
                       Kaiserslautern (Germany), 25 May 2017 -
                       27 May 2017},
      subtyp        = {Invited},
      cin          = {ICS-3},
      cid          = {I:(DE-Juel1)ICS-3-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/830383},
}