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@ARTICLE{Oskamp:830411,
      author       = {Oskamp, A. and Wedekind, F. and Kroll, T. and Elmenhorst,
                      D. and Bauer, A.},
      title        = {{N}eurotransmitter receptor availability in the rat brain
                      is constant in a 24 hour-period},
      journal      = {Chronobiology international},
      volume       = {34},
      number       = {7},
      issn         = {1525-6073},
      address      = {Philadelphia, Pa.},
      publisher    = {Taylor $\&$ Francis},
      reportid     = {FZJ-2017-03960},
      pages        = {1 - 10},
      year         = {2017},
      abstract     = {Wakefulness and sleep are fundamental characteristics of
                      the brain. We, therefore, hypothesized that transmitter
                      systems contribute to their regulation and will exhibit
                      circadian alterations.We assessed the concentration of
                      various neurotransmitter receptors and transporters
                      including adenosinergic (A1AR, A2AAR, and ENT1),
                      dopaminergic (D1R, D2R, and DAT), and serotonergic (5-HT2AR)
                      target proteins. Adult male Sprague Dawley rats were used
                      and maintained in a 12 h light: 12 h dark cycle (lights on
                      from 07:00 h to 19:00 h). We measured receptor and
                      transporter concentrations in different brain regions,
                      including caudate putamen, basal forebrain, and cortex in 4
                      hour-intervals over a 24 hour-period using quantitative in
                      vitro autoradiography.Investigated receptors and
                      transporters showed no fluctuations in any of the analyzed
                      regions using one-way ANOVA. Only in the horizontal diagonal
                      band of Broca, the difference of A1AR concentration between
                      light and dark phases (t-test) as well as the cosinor
                      analysis of the 24 hour-course were significant, suggesting
                      that this region underlies receptor fluctuations.Our
                      findings suggest that the availability of the investigated
                      neurotransmitter receptors and transporters does not undergo
                      changes in a 24 hour-period. While there are reports on
                      changes in adenosine and dopamine receptors during sleep
                      deprivation, we found no changes in the investigated
                      adenosine, dopamine, and serotonin receptors during regular
                      and undisturbed day-night cycles.},
      cin          = {INM-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28548869},
      UT           = {WOS:000413356500004},
      doi          = {10.1080/07420528.2017.1325370},
      url          = {https://juser.fz-juelich.de/record/830411},
}