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@ARTICLE{Kirchner:830413,
      author       = {Kirchner, Julian and Schaarschmidt, Benedikt Michael and
                      Sawicki, Lino Morris and Heusch, Philipp and Hautzel,
                      Hubertus and Ermert, Johannes and Rabenalt, Robert and
                      Antoch, Gerald and Buchbender, Christian},
      title        = {{E}valuation of {P}ractical {I}nterpretation {H}urdles in
                      68{G}a-{PSMA} {PET}/{CT} in 55 {P}atients},
      journal      = {Clinical nuclear medicine},
      volume       = {42},
      number       = {7},
      issn         = {0363-9762},
      address      = {Philadelphia, Pa.},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {FZJ-2017-03962},
      pages        = {e322 - e327},
      year         = {2017},
      abstract     = {PurposeTo investigate the physiologic 68Ga-PSMA
                      distribution and evaluate focal or diffuse radiotracer
                      uptake in nonprostate cancer malignancies and in incidental
                      findings.Methods68Ga-PSMA PET/CT scans in 55 men performed
                      for prostate cancer (49) or renal cell carcinoma (6) staging
                      were analyzed retrospectively. Two radiologists evaluated
                      the datasets in 2 reading sessions. First, physiological
                      68Ga-PSMA uptake was evaluated. Second, scans were analyzed
                      for incidental uptake. SUVmax and SUVmean were recorded.
                      Other imaging modalities, histopathology, or clinical
                      follow-up served as standard of reference.ResultsHomogenous
                      68Ga-PSMA uptake of the lacrimal glands (SUVmax, 15.7 ±
                      7.2), parotid glands (SUVmax, 24.4 ± 8.1), submandibular
                      glands (SUVmax, 26.7 ± 7.1), vocal cords (SUVmax, 8.4 ±
                      3), Waldeyer ring (SUVmax, 10.4 ± 4.3), liver (SUVmax, 8.2
                      ± 2.5), spleen (SUVmax, 10.9 ± 3.9), kidneys (SUVmax, 66.4
                      ± 25.4), and pars descendens duodeni (SUVmax, 17.6 ± 8.9)
                      was observed in all patients. In $65\%$ and $36\%,$
                      respectively, homogenous 68Ga-PSMA uptake of the colon
                      descendens (SUVmax, 10.6 ± 9.2) and the rectum (SUVmax, 3.7
                      ± 1.1) was found. Approximately $22\%$ exhibited a
                      68Ga-PSMA uptake of the thyroid (SUVmax, 4.5 ± 1.2), and
                      $21\%$ exhibited a 68Ga-PSMA uptake of the knee’s synovia
                      (SUVmax, 2.9 ± 0.2). Furthermore, 68Ga-PSMA uptake was
                      found in 1 patient because of fibrous dysplasia of the right
                      os ilium (SUVmax, 7.7).ConclusionsPhysiologic distribution
                      of 68Ga-PSMA comprises uptake in lacrimal and salivary
                      glands, vocal cords, Waldeyer ring, liver, spleen, and
                      kidneys as well as various parts of the intestine. Moreover,
                      nonspecific tracer uptake is regularly found in the thyroid
                      and the synovia of the knee. Incidental 68Ga-PSMA uptake can
                      occasionally reveal nonprostate cancer–associated
                      remodeling processes, such as fibrous dysplasia.},
      cin          = {INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000402747200001},
      pubmed       = {pmid:28481787},
      doi          = {10.1097/RLU.0000000000001672},
      url          = {https://juser.fz-juelich.de/record/830413},
}