000830498 001__ 830498
000830498 005__ 20240625095111.0
000830498 0247_ $$2doi$$a10.1016/j.bmcl.2017.04.026
000830498 0247_ $$2ISSN$$a0960-894X
000830498 0247_ $$2ISSN$$a1464-3405
000830498 0247_ $$2WOS$$aWOS:000402472600004
000830498 037__ $$aFZJ-2017-04039
000830498 082__ $$a540
000830498 1001_ $$0P:(DE-HGF)0$$aHendriks, Christine M. M.$$b0
000830498 245__ $$aSulfoximines as ATR inhibitors: Analogs of VE-821
000830498 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2017
000830498 3367_ $$2DRIVER$$aarticle
000830498 3367_ $$2DataCite$$aOutput Types/Journal article
000830498 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1497010275_12002
000830498 3367_ $$2BibTeX$$aARTICLE
000830498 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000830498 3367_ $$00$$2EndNote$$aJournal Article
000830498 520__ $$aThe ATM- and Rad3-related (ATR) kinases play a key role in DNA repair processes and thus ATR is an attractive target for cancer therapy. Here we designed and synthesized sulfilimidoyl- and sulfoximidoyl-substituted analogs of the sulfone VE-821, a reported ATR inhibitor. The properties of these analogs have been investigated by calculating physicochemical parameters and studying their potential to specifically inhibit ATR in cells. Prolonged inhibition of ATR by the analogs in a Burkitt lymphoma cell line resulted in enhanced DNA damage and a substantial amount of apoptosis. Together our findings suggest that the sulfilimidoyl- and sulfoximidoyl-substituted analogs are efficient ATR inhibitors.
000830498 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000830498 536__ $$0G:(DE-HGF)POF3-511$$a511 - Computational Science and Mathematical Methods (POF3-511)$$cPOF3-511$$fPOF III$$x1
000830498 588__ $$aDataset connected to CrossRef
000830498 7001_ $$0P:(DE-HGF)0$$aHartkamp, Jörg$$b1
000830498 7001_ $$0P:(DE-HGF)0$$aWiezorek, Stefan$$b2
000830498 7001_ $$0P:(DE-HGF)0$$aSteinkamp, Anne-Dorothee$$b3
000830498 7001_ $$0P:(DE-Juel1)145921$$aRossetti, Giulia$$b4
000830498 7001_ $$0P:(DE-HGF)0$$aLüscher, Bernhard$$b5
000830498 7001_ $$0P:(DE-HGF)0$$aBolm, Carsten$$b6$$eCorresponding author
000830498 773__ $$0PERI:(DE-600)1501505-1$$a10.1016/j.bmcl.2017.04.026$$gVol. 27, no. 12, p. 2659 - 2662$$n12$$p2659 - 2662$$tBioorganic & medicinal chemistry letters$$v27$$x0960-894X$$y2017
000830498 8564_ $$uhttps://juser.fz-juelich.de/record/830498/files/1-s2.0-S0960894X17304018-main.pdf$$yRestricted
000830498 8564_ $$uhttps://juser.fz-juelich.de/record/830498/files/1-s2.0-S0960894X17304018-main.gif?subformat=icon$$xicon$$yRestricted
000830498 8564_ $$uhttps://juser.fz-juelich.de/record/830498/files/1-s2.0-S0960894X17304018-main.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000830498 8564_ $$uhttps://juser.fz-juelich.de/record/830498/files/1-s2.0-S0960894X17304018-main.jpg?subformat=icon-180$$xicon-180$$yRestricted
000830498 8564_ $$uhttps://juser.fz-juelich.de/record/830498/files/1-s2.0-S0960894X17304018-main.jpg?subformat=icon-640$$xicon-640$$yRestricted
000830498 8564_ $$uhttps://juser.fz-juelich.de/record/830498/files/1-s2.0-S0960894X17304018-main.pdf?subformat=pdfa$$xpdfa$$yRestricted
000830498 909CO $$ooai:juser.fz-juelich.de:830498$$pVDB
000830498 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)145921$$aForschungszentrum Jülich$$b4$$kFZJ
000830498 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000830498 9131_ $$0G:(DE-HGF)POF3-511$$1G:(DE-HGF)POF3-510$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lSupercomputing & Big Data$$vComputational Science and Mathematical Methods$$x1
000830498 9141_ $$y2017
000830498 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000830498 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000830498 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000830498 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000830498 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBIOORG MED CHEM LETT : 2015
000830498 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000830498 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000830498 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000830498 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000830498 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000830498 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000830498 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000830498 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000830498 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000830498 9201_ $$0I:(DE-Juel1)IAS-5-20120330$$kIAS-5$$lComputational Biomedicine$$x0
000830498 9201_ $$0I:(DE-Juel1)JSC-20090406$$kJSC$$lJülich Supercomputing Center$$x1
000830498 9201_ $$0I:(DE-Juel1)INM-9-20140121$$kINM-9$$lComputational Biomedicine$$x2
000830498 980__ $$ajournal
000830498 980__ $$aVDB
000830498 980__ $$aI:(DE-Juel1)IAS-5-20120330
000830498 980__ $$aI:(DE-Juel1)JSC-20090406
000830498 980__ $$aI:(DE-Juel1)INM-9-20140121
000830498 980__ $$aUNRESTRICTED