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@ARTICLE{Hendriks:830498,
      author       = {Hendriks, Christine M. M. and Hartkamp, Jörg and Wiezorek,
                      Stefan and Steinkamp, Anne-Dorothee and Rossetti, Giulia and
                      Lüscher, Bernhard and Bolm, Carsten},
      title        = {{S}ulfoximines as {ATR} inhibitors: {A}nalogs of {VE}-821},
      journal      = {Bioorganic $\&$ medicinal chemistry letters},
      volume       = {27},
      number       = {12},
      issn         = {0960-894X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2017-04039},
      pages        = {2659 - 2662},
      year         = {2017},
      abstract     = {The ATM- and Rad3-related (ATR) kinases play a key role in
                      DNA repair processes and thus ATR is an attractive target
                      for cancer therapy. Here we designed and synthesized
                      sulfilimidoyl- and sulfoximidoyl-substituted analogs of the
                      sulfone VE-821, a reported ATR inhibitor. The properties of
                      these analogs have been investigated by calculating
                      physicochemical parameters and studying their potential to
                      specifically inhibit ATR in cells. Prolonged inhibition of
                      ATR by the analogs in a Burkitt lymphoma cell line resulted
                      in enhanced DNA damage and a substantial amount of
                      apoptosis. Together our findings suggest that the
                      sulfilimidoyl- and sulfoximidoyl-substituted analogs are
                      efficient ATR inhibitors.},
      cin          = {IAS-5 / JSC / INM-9},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)JSC-20090406 /
                      I:(DE-Juel1)INM-9-20140121},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572) / 511 -
                      Computational Science and Mathematical Methods (POF3-511)},
      pid          = {G:(DE-HGF)POF3-572 / G:(DE-HGF)POF3-511},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000402472600004},
      doi          = {10.1016/j.bmcl.2017.04.026},
      url          = {https://juser.fz-juelich.de/record/830498},
}