000834099 001__ 834099
000834099 005__ 20220930130125.0
000834099 0247_ $$2doi$$a10.1007/s40336-017-0225-z
000834099 0247_ $$2ISSN$$a2281-5872
000834099 0247_ $$2ISSN$$a2281-7565
000834099 0247_ $$2Handle$$a2128/14771
000834099 0247_ $$2WOS$$aWOS:000401710600003
000834099 037__ $$aFZJ-2017-04100
000834099 041__ $$aEnglish
000834099 082__ $$a610
000834099 1001_ $$0P:(DE-Juel1)141877$$aFilss, Christian$$b0
000834099 245__ $$aAmino acid PET and MR perfusion imaging in brain tumours
000834099 260__ $$aBerlin$$bSpringer Milan$$c2017
000834099 3367_ $$2DRIVER$$aarticle
000834099 3367_ $$2DataCite$$aOutput Types/Journal article
000834099 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1498716571_11468
000834099 3367_ $$2BibTeX$$aARTICLE
000834099 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000834099 3367_ $$00$$2EndNote$$aJournal Article
000834099 520__ $$aPurposeDespite the excellent capacity of the conventional MRI to image brain tumours, problems remain in answering a number of critical diagnostic questions. To overcome these diagnostic shortcomings, PET using radiolabeled amino acids and perfusion-weighted imaging (PWI) are currently under clinical evaluation. The role of amino acid PET and PWI in different diagnostic challenges in brain tumours is controversial.MethodsBased on the literature and experience of our centres in correlative imaging with PWI and PET using O-(2-[18F]fluoroethyl)-l-tyrosine or 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine, the current role and shortcomings of amino acid PET and PWI in different diagnostic challenges in brain tumours are reviewed. Literature searches were performed on PubMed, and additional literature was retrieved from the reference lists of identified articles. In particular, all studies in which amino acid PET was directly compared with PWI were included.ResultsPWI is more readily available, but requires substantial expertise and is more sensitive to artifacts than amino acid PET. At initial diagnosis, PWI and amino acid PET can help to define a site for biopsy but amino acid PET appears to be more powerful to define the tumor extent. Both methods are helpful to differentiate progression or recurrence from unspecific posttherapeutic changes. Assessment of therapeutic efficacy can be achieved especially with amino acid PET, while the data with PWI are sparse.ConclusionBoth PWI and amino acid PET add valuable diagnostic information to the conventional MRI in the assessment of patients with brain tumours, but further studies are necessary to explore the complementary nature of these two methods.
000834099 536__ $$0G:(DE-HGF)POF3-573$$a573 - Neuroimaging (POF3-573)$$cPOF3-573$$fPOF III$$x0
000834099 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x1
000834099 588__ $$aDataset connected to CrossRef
000834099 7001_ $$0P:(DE-HGF)0$$aCicone, Francesco$$b1
000834099 7001_ $$0P:(DE-Juel1)131794$$aShah, N. J.$$b2
000834099 7001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b3
000834099 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b4$$eCorresponding author
000834099 773__ $$0PERI:(DE-600)2712000-4$$a10.1007/s40336-017-0225-z$$gVol. 5, no. 3, p. 209 - 223$$n3$$p209 - 223$$tClinical and translational imaging$$v5$$x2281-7565$$y2017
000834099 8564_ $$uhttps://juser.fz-juelich.de/record/834099/files/10.1007_s40336-017-0225-z.pdf$$yOpenAccess
000834099 8564_ $$uhttps://juser.fz-juelich.de/record/834099/files/10.1007_s40336-017-0225-z.gif?subformat=icon$$xicon$$yOpenAccess
000834099 8564_ $$uhttps://juser.fz-juelich.de/record/834099/files/10.1007_s40336-017-0225-z.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
000834099 8564_ $$uhttps://juser.fz-juelich.de/record/834099/files/10.1007_s40336-017-0225-z.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
000834099 8564_ $$uhttps://juser.fz-juelich.de/record/834099/files/10.1007_s40336-017-0225-z.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
000834099 8564_ $$uhttps://juser.fz-juelich.de/record/834099/files/10.1007_s40336-017-0225-z.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000834099 8767_ $$82936104356$$92017-06-27$$d2017-08-10$$eHybrid-OA$$jZahlung erfolgt
000834099 909CO $$ooai:juser.fz-juelich.de:834099$$popenCost$$pVDB$$pdriver$$pOpenAPC$$popen_access$$popenaire$$pdnbdelivery
000834099 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000834099 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000834099 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000834099 915__ $$0StatID:(DE-HGF)0199$$2"StatID$$aClarivate Analytics Master Journal List
000834099 9141_ $$y2017
000834099 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)141877$$aForschungszentrum Jülich$$b0$$kFZJ
000834099 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131794$$aForschungszentrum Jülich$$b2$$kFZJ
000834099 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)143792$$aForschungszentrum Jülich$$b3$$kFZJ
000834099 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131777$$aForschungszentrum Jülich$$b4$$kFZJ
000834099 9131_ $$0G:(DE-HGF)POF3-573$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vNeuroimaging$$x0
000834099 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x1
000834099 9201_ $$0I:(DE-Juel1)INM-4-20090406$$kINM-4$$lPhysik der Medizinischen Bildgebung$$x0
000834099 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x1
000834099 9201_ $$0I:(DE-82)080010_20140620$$kJARA-BRAIN$$lJARA-BRAIN$$x2
000834099 980__ $$ajournal
000834099 980__ $$aVDB
000834099 980__ $$aUNRESTRICTED
000834099 980__ $$aI:(DE-Juel1)INM-4-20090406
000834099 980__ $$aI:(DE-Juel1)INM-3-20090406
000834099 980__ $$aI:(DE-82)080010_20140620
000834099 980__ $$aAPC
000834099 9801_ $$aAPC
000834099 9801_ $$aFullTexts