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@ARTICLE{Filss:834099,
      author       = {Filss, Christian and Cicone, Francesco and Shah, N. J. and
                      Galldiks, Norbert and Langen, Karl-Josef},
      title        = {{A}mino acid {PET} and {MR} perfusion imaging in brain
                      tumours},
      journal      = {Clinical and translational imaging},
      volume       = {5},
      number       = {3},
      issn         = {2281-7565},
      address      = {Berlin},
      publisher    = {Springer Milan},
      reportid     = {FZJ-2017-04100},
      pages        = {209 - 223},
      year         = {2017},
      abstract     = {PurposeDespite the excellent capacity of the conventional
                      MRI to image brain tumours, problems remain in answering a
                      number of critical diagnostic questions. To overcome these
                      diagnostic shortcomings, PET using radiolabeled amino acids
                      and perfusion-weighted imaging (PWI) are currently under
                      clinical evaluation. The role of amino acid PET and PWI in
                      different diagnostic challenges in brain tumours is
                      controversial.MethodsBased on the literature and experience
                      of our centres in correlative imaging with PWI and PET using
                      O-(2-[18F]fluoroethyl)-l-tyrosine or
                      3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine, the current
                      role and shortcomings of amino acid PET and PWI in different
                      diagnostic challenges in brain tumours are reviewed.
                      Literature searches were performed on PubMed, and additional
                      literature was retrieved from the reference lists of
                      identified articles. In particular, all studies in which
                      amino acid PET was directly compared with PWI were
                      included.ResultsPWI is more readily available, but requires
                      substantial expertise and is more sensitive to artifacts
                      than amino acid PET. At initial diagnosis, PWI and amino
                      acid PET can help to define a site for biopsy but amino acid
                      PET appears to be more powerful to define the tumor extent.
                      Both methods are helpful to differentiate progression or
                      recurrence from unspecific posttherapeutic changes.
                      Assessment of therapeutic efficacy can be achieved
                      especially with amino acid PET, while the data with PWI are
                      sparse.ConclusionBoth PWI and amino acid PET add valuable
                      diagnostic information to the conventional MRI in the
                      assessment of patients with brain tumours, but further
                      studies are necessary to explore the complementary nature of
                      these two methods.},
      cin          = {INM-4 / INM-3 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-3-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573) / 572 - (Dys-)function and
                      Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-573 / G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000401710600003},
      doi          = {10.1007/s40336-017-0225-z},
      url          = {https://juser.fz-juelich.de/record/834099},
}