%0 Journal Article
%A Kireev, Dmitry
%A Seyock, Silke
%A Lewen, Johannes
%A Maybeck, Vanessa
%A Wolfrum, Bernhard
%A Offenhäusser, Andreas
%T Graphene Multielectrode Arrays as a Versatile Tool for Extracellular Measurements552
%J Advanced healthcare materials
%V 6
%N 12
%@ 2192-2640
%C Weinheim
%I Wiley-VCH
%M FZJ-2017-04104
%P 1601433 -
%D 2017
%X Graphene multielectrode arrays (GMEAs) presented in this work are used for cardio and neuronal extracellular recordings. The advantages of the graphene as a part of the multielectrode arrays are numerous: from a general flexibility and biocompatibility to the unique electronic properties of graphene. The devices used for extensive in vitro studies of a cardiac-like cell line and cortical neuronal networks show excellent ability to extracellularly detect action potentials with signal to noise ratios in the range of 45 ± 22 for HL-1 cells and 48 ± 26 for spontaneous bursting/spiking neuronal activity. Complex neuronal bursting activity patterns as well as a variety of characteristic shapes of HL-1 action potentials are recorded with the GMEAs. This paper illustrates that the potential applications of the GMEAs in biological and medical research are still numerous and diverse.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000403787500006
%$ pmid:28371490
%R 10.1002/adhm.201601433
%U https://juser.fz-juelich.de/record/834103