%0 Journal Article
%A Mishin, A. V.
%A Luginina, A. P.
%A Potapenko, A. P.
%A Borshchevskiy, Valentin
%A Katritch, V.
%A Edelweiss, E.
%A Okhrimenko, I. S.
%A Gordeliy, Valentin
%A Cherezov, V. G.
%T Expression and purification of an engineered human endothelin receptor B in a monomeric form
%J Doklady biochemistry and biophysics
%V 467
%N 1
%@ 1607-6729
%C Dordrecht []
%I Springer Science & Business Media B.V.
%M FZJ-2017-04112
%P 157–161
%D 2016
%X In humans, two endothelin receptors, ETa and ETb, are activated by three endogenous 21-mer cyclic peptides, ET-1, ET-2, and ET-3, which control various physiological processes, including vasoconstriction, vasodilation, and stimulation of cell proliferation. The first stage of this study it to produce a stable solubilized and purified receptor in a monodisperse state. This article is focused on the engineering, expression, purification, and characterization of the endothelin receptor B for subsequent structural and functional studies.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000376467500021
%$ pmid:27193723
%R 10.1134/S1607672916020216
%U https://juser.fz-juelich.de/record/834111