TY  - JOUR
AU  - Mishin, A. V.
AU  - Luginina, A. P.
AU  - Potapenko, A. P.
AU  - Borshchevskiy, Valentin
AU  - Katritch, V.
AU  - Edelweiss, E.
AU  - Okhrimenko, I. S.
AU  - Gordeliy, Valentin
AU  - Cherezov, V. G.
TI  - Expression and purification of an engineered human endothelin receptor B in a monomeric form
JO  - Doklady biochemistry and biophysics
VL  - 467
IS  - 1
SN  - 1607-6729
CY  - Dordrecht []
PB  - Springer Science & Business Media B.V.
M1  - FZJ-2017-04112
SP  - 157–161
PY  - 2016
AB  - In humans, two endothelin receptors, ETa and ETb, are activated by three endogenous 21-mer cyclic peptides, ET-1, ET-2, and ET-3, which control various physiological processes, including vasoconstriction, vasodilation, and stimulation of cell proliferation. The first stage of this study it to produce a stable solubilized and purified receptor in a monodisperse state. This article is focused on the engineering, expression, purification, and characterization of the endothelin receptor B for subsequent structural and functional studies.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000376467500021
C6  - pmid:27193723
DO  - DOI:10.1134/S1607672916020216
UR  - https://juser.fz-juelich.de/record/834111
ER  -