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@ARTICLE{Langen:834118,
      author       = {Langen, Karl-Josef and Stoffels, Gabriele and Filss,
                      Christian and Heinzel, Alexander and Stegmayr, Carina and
                      Lohmann, Philipp and Willuweit, Antje and Neumaier, Bernd
                      and Mottaghy, Felix M. and Galldiks, Norbert},
      title        = {{I}maging of amino acid transport in brain tumours:
                      {P}ositron emission tomography with {O}-(2-[ 18
                      {F}]fluoroethyl)- {L} -tyrosine ({FET})},
      journal      = {Methods},
      volume       = {130},
      issn         = {1046-2023},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2017-04118},
      pages        = {124-134},
      year         = {2017},
      abstract     = {The assessment of cerebral gliomas using magnetic resonance
                      imaging (MRI) provides excellent structural images but
                      cannot solve all diagnostic problems satisfactorily. The
                      differentiation of tumour tissue from non-neoplastic changes
                      may be difficult especially in the post-treatment phase. In
                      recent years, positron emission tomography (PET) using
                      radiolabelled amino acids has gained considerable interest
                      as an additional tool to improve the diagnosis of cerebral
                      gliomas and brain metastases. A key step for this
                      advancement was the development of the F-18 labelled amino
                      acid O-(2-[18F]fluoroethyl)-L-tyrosine (FET) which has
                      spread rapidly in the last decade and replaced carbon-11
                      labelled amino acid tracers such as 11C-methyl-L-methionine
                      (MET) in many centres in Europe. FET can be produced with
                      high efficiency and distributed in a satellite concept like
                      2-[18F]fluoro-2-deoxy-D-glucose (FDG). Furthermore, FET
                      exhibits favourable properties such as high in vivo
                      stability, high tumour to background contrast and tissue
                      specific tracer kinetics, which provides additional
                      information for tumour grading or differential diagnosis.
                      The Response Assessment in Neuro-Oncology (RANO) working
                      group — an international effort to develop new
                      standardized response criteria for clinical trials in brain
                      tumours — has recently recommended the additional use of
                      amino acid PET imaging for brain tumour management. FET PET
                      can provide important diagnostic information in crucial
                      situations such as the definition of biopsy site, the
                      delineation of cerebral gliomas for therapy planning,
                      sensitive monitoring of treatment response and an improved
                      differentiation of tumour recurrence from treatment-related
                      changes. In this article the basic information,
                      methodological aspects and the actual status of clinical
                      application of FET PET are reviewed.},
      cin          = {INM-4 / INM-3 / INM-5 / JARA-BRAIN},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-3-20090406 /
                      I:(DE-Juel1)INM-5-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28552264},
      UT           = {WOS:000414879700014},
      doi          = {10.1016/j.ymeth.2017.05.019},
      url          = {https://juser.fz-juelich.de/record/834118},
}