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@ARTICLE{Dillen:834119,
      author       = {Dillen, Kim and Jacobs, Heidi I. L. and Kukolja, Juraj and
                      Richter, Nils and von Reutern, Boris and Onur, Özgür and
                      Langen, Karl-Josef and Fink, Gereon R.},
      title        = {{F}unctional {D}isintegration of the {D}efault {M}ode
                      {N}etwork in {P}rodromal {A}lzheimer’s {D}isease},
      journal      = {Journal of Alzheimer's disease},
      volume       = {59},
      number       = {1},
      issn         = {1875-8908},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2017-04119},
      pages        = {169-187},
      year         = {2017},
      abstract     = {Neurodegenerative brain changes can affect the functional
                      connectivity strength between nodes of the default-mode
                      network (DMN), which may underlie changes in cognitive
                      performance. It remains unclear how the functional
                      connectivity strength of DMN nodes differs from healthy to
                      pathological aging and whether these changes are cognitively
                      relevant. We used resting-state functional magnetic
                      resonance imaging to investigate the functional connectivity
                      strength across five DMN nodes in 25 healthy controls (HC),
                      28 subjective cognitive decline (SCD) participants, and 25
                      prodromal Alzheimer’s disease (AD) patients. After
                      identifying the ventral medial prefrontal cortex (vmPFC),
                      posterior cingulate cortex (PCC), retrosplenial cortex
                      (RSC), inferior parietal lobule, and the hippocampus we
                      investigated the functional strength between DMN nodes using
                      temporal network modeling. Functional coupling of the vmPFC
                      and PCC in prodromal AD patients was disrupted. This
                      vmPFC-PCC coupling correlated positively with memory
                      performance in prodromal AD. Furthermore, the hippocampus
                      de-coupled from posterior DMN nodes in SCD and prodromal AD
                      patients. There was no coupling between the hippocampus and
                      the anterior DMN. Additional mediation analyses indicated
                      that the RSC enables communication between the hippocampus
                      and DMN regions in HC but none of the other two groups.
                      These results suggest an anterior-posterior disconnection
                      and a hippocampal de-coupling from posterior DMN nodes with
                      disease progression. Hippocampal de-coupling already
                      occurring in SCD may provide valuable information for the
                      development of a functional biomarker.},
      cin          = {INM-3 / INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000404876400017},
      pubmed       = {pmid:28598839},
      doi          = {10.3233/JAD-161120},
      url          = {https://juser.fz-juelich.de/record/834119},
}