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@ARTICLE{Hoenig:834205,
      author       = {Hoenig, Merle Christine and Bischof, Gerard Nisal and
                      Hammes, Jochen and Faber, Jennifer and Fliessbach, Klaus and
                      van Eimeren, Thilo and Drzezga, Alexander},
      title        = {{T}au pathology and cognitive reserve in {A}lzheimer's
                      disease},
      journal      = {Neurobiology of aging},
      volume       = {57},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2017-04188},
      pages        = {1 - 7},
      year         = {2017},
      abstract     = {Cognitive reserve (CR) is defined as the ability to
                      maintain functionality despite accumulating pathology.
                      Education has been used as a proxy for CR. For example, by
                      using positron emission tomography imaging, higher educated
                      Alzheimer's disease (AD) patients presented increased
                      amyloid β pathology than lower educated patients despite
                      equal symptomatology. Whether similar associations exist for
                      in vivo tau pathology remains elusive. We utilized
                      [18F]AV-1451 positron emission tomography imaging to examine
                      whether high-educated AD patients (n = 12) present more
                      severe tau pathology compared with low-educated patients (n
                      = 12) despite equal clinical severity in regions of interest
                      corresponding to the pathologic disease stages defined by
                      Braak $\&$ Braak. We report tau pathology in advanced Braak
                      stages associated with parietal and frontal regions in
                      high-educated AD patients, whereas in low-educated AD
                      patients tau accumulation is still confined to lower Braak
                      stages associated with temporal and cingulate regions.
                      Highly educated AD patients seem to be able to tolerate more
                      tau tangle pathology than lower educated patients with
                      comparable cognitive impairment supporting the cognitive
                      reserve hypothesis.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000406296500002},
      pubmed       = {pmid:28577411},
      doi          = {10.1016/j.neurobiolaging.2017.05.004},
      url          = {https://juser.fz-juelich.de/record/834205},
}