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000834206 1001_ $$0P:(DE-HGF)0$$aFenz, Susanne F.$$b0
000834206 245__ $$aMembrane fluctuations mediate lateral interaction between cadherin bonds
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000834206 520__ $$aThe integrity of living tissues is maintained by adhesion domains of trans-bonds formed between cadherin proteins residing on opposing membranes of neighbouring cells. These domains are stabilized by lateral cis-interactions between the cadherins on the same cell. However, the origin of cis-interactions remains perplexing since they are detected only in the context of trans-bonds. By combining experimental, analytical and computational approaches, we identify bending fluctuations of membranes as a source of long-range cis-interactions, and a regulator of trans-interactions. Specifically, nanometric membrane bending and fluctuations introduce cooperative effects that modulate the affinity and binding/unbinding rates for trans-dimerization, dramatically affecting the nucleation and growth of adhesion domains. Importantly, this regulation relies on physical principles and not on details of protein–protein interactions. These omnipresent fluctuations can thus act as a generic control mechanism in all types of cell adhesion, suggesting a hitherto unknown physiological role for recently identified active fluctuations of cellular membranes.
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000834206 7001_ $$0P:(DE-HGF)0$$aSchmidt, Daniel$$b2
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000834206 7001_ $$0P:(DE-HGF)0$$aSeifert, Udo$$b4
000834206 7001_ $$0P:(DE-HGF)0$$aSengupta, Kheya$$b5
000834206 7001_ $$0P:(DE-HGF)0$$aSmith, Ana-Sunčana$$b6$$eCorresponding author
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