TY  - JOUR
AU  - Fenz, Susanne F.
AU  - Bihr, Timo
AU  - Schmidt, Daniel
AU  - Merkel, Rudolf
AU  - Seifert, Udo
AU  - Sengupta, Kheya
AU  - Smith, Ana-Sunčana
TI  - Membrane fluctuations mediate lateral interaction between cadherin bonds
JO  - Nature physics
VL  - 13
SN  - 1745-2481
CY  - Basingstoke
PB  - Nature Publishing Group
M1  - FZJ-2017-04189
SP  - 906–913
PY  - 2017
AB  - The integrity of living tissues is maintained by adhesion domains of trans-bonds formed between cadherin proteins residing on opposing membranes of neighbouring cells. These domains are stabilized by lateral cis-interactions between the cadherins on the same cell. However, the origin of cis-interactions remains perplexing since they are detected only in the context of trans-bonds. By combining experimental, analytical and computational approaches, we identify bending fluctuations of membranes as a source of long-range cis-interactions, and a regulator of trans-interactions. Specifically, nanometric membrane bending and fluctuations introduce cooperative effects that modulate the affinity and binding/unbinding rates for trans-dimerization, dramatically affecting the nucleation and growth of adhesion domains. Importantly, this regulation relies on physical principles and not on details of protein–protein interactions. These omnipresent fluctuations can thus act as a generic control mechanism in all types of cell adhesion, suggesting a hitherto unknown physiological role for recently identified active fluctuations of cellular membranes.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000409235100026
DO  - DOI:10.1038/nphys4138
UR  - https://juser.fz-juelich.de/record/834206
ER  -