Home > Publications database > Membrane fluctuations mediate lateral interaction between cadherin bonds > print

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005     20210129230557.0
024 7 _ |a 10.1038/nphys4138
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100 1 _ |a Fenz, Susanne F.
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245 _ _ |a Membrane fluctuations mediate lateral interaction between cadherin bonds
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520 _ _ |a The integrity of living tissues is maintained by adhesion domains of trans-bonds formed between cadherin proteins residing on opposing membranes of neighbouring cells. These domains are stabilized by lateral cis-interactions between the cadherins on the same cell. However, the origin of cis-interactions remains perplexing since they are detected only in the context of trans-bonds. By combining experimental, analytical and computational approaches, we identify bending fluctuations of membranes as a source of long-range cis-interactions, and a regulator of trans-interactions. Specifically, nanometric membrane bending and fluctuations introduce cooperative effects that modulate the affinity and binding/unbinding rates for trans-dimerization, dramatically affecting the nucleation and growth of adhesion domains. Importantly, this regulation relies on physical principles and not on details of protein–protein interactions. These omnipresent fluctuations can thus act as a generic control mechanism in all types of cell adhesion, suggesting a hitherto unknown physiological role for recently identified active fluctuations of cellular membranes.
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700 1 _ |a Bihr, Timo
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700 1 _ |a Schmidt, Daniel
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700 1 _ |a Merkel, Rudolf
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700 1 _ |a Seifert, Udo
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700 1 _ |a Sengupta, Kheya
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700 1 _ |a Smith, Ana-Sunčana
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773 _ _ |a 10.1038/nphys4138
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