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@ARTICLE{Caspers:834224,
      author       = {Caspers, Julian and Mathys, Christian and Hoffstaedter,
                      Felix and Südmeyer, Martin and Cieslik, Edna C. and
                      Rubbert, Christian and Hartmann, Christian J. and Eickhoff,
                      Claudia R. and Reetz, Kathrin and Grefkes, Christian and
                      Michely, Jochen and Turowski, Bernd and Schnitzler, Alfons
                      and Eickhoff, Simon},
      title        = {{D}ifferential {F}unctional {C}onnectivity {A}lterations of
                      {T}wo {S}ubdivisions within the {R}ight dl{PFC} in
                      {P}arkinson's {D}isease},
      journal      = {Frontiers in human neuroscience},
      volume       = {11},
      issn         = {1662-5161},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2017-04206},
      pages        = {288},
      year         = {2017},
      abstract     = {Patients suffering from Parkinson's disease (PD) often show
                      impairments in executive function (EF) like decision-making
                      and action control. The right dorsolateral prefrontal cortex
                      (dlPFC) has been strongly implicated in EF in healthy
                      subjects and has repeatedly been reported to show
                      alterations related to EF impairment in PD. Recently, two
                      key regions for cognitive action control have been
                      identified within the right dlPFC by co-activation based
                      parcellation. While the posterior region is engaged in
                      rather basal EF like stimulus integration and working
                      memory, the anterior region has a more abstract, supervisory
                      function. To investigate whether these functionally distinct
                      subdivisions of right dlPFC are differentially affected in
                      PD, we analyzed resting-state functional connectivity (FC)
                      in 39 PD patients and 44 age- and gender-matched healthy
                      controls. Patients were examined both after at least 12 h
                      withdrawal of dopaminergic drugs (OFF) and under their
                      regular dopaminergic medication (ON). We found that only the
                      posterior right dlPFC subdivision shows FC alterations in
                      PD, while the anterior part remains unaffected. PD-related
                      decreased FC with posterior right dlPFC was found in the
                      bilateral medial posterior parietal cortex (mPPC) and left
                      dorsal premotor region (PMd) in the OFF state. In the
                      medical ON, FC with left PMd normalized, while decoupling
                      with bilateral mPPC remained. Furthermore, we observed
                      increased FC between posterior right dlPFC and the bilateral
                      dorsomedial prefrontal cortex (dmPFC) in PD in the ON state.
                      Our findings point to differential disturbances of right
                      dlPFC connectivity in PD, which relate to its hierarchical
                      organization of EF processing by stronger affecting the
                      functionally basal posterior aspect than the hierarchically
                      higher anterior part.},
      cin          = {INM-3 / INM-1 / INM-11 / INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      I:(DE-Juel1)INM-11-20170113 / I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000402567700001},
      pubmed       = {pmid:28611616},
      doi          = {10.3389/fnhum.2017.00288},
      url          = {https://juser.fz-juelich.de/record/834224},
}