000834560 001__ 834560
000834560 005__ 20210129230712.0
000834560 0247_ $$2doi$$a10.1162/jocn_a_01040
000834560 0247_ $$2ISSN$$a0898-929X
000834560 0247_ $$2ISSN$$a1530-8898
000834560 0247_ $$2WOS$$aWOS:000392229900008
000834560 0247_ $$2altmetric$$aaltmetric:12061890
000834560 0247_ $$2pmid$$apmid:27626228
000834560 037__ $$aFZJ-2017-04488
000834560 082__ $$a400
000834560 1001_ $$0P:(DE-Juel1)169149$$aTrempler, Ima$$b0
000834560 245__ $$aFrontostriatal Contribution to the Interplay of Flexibility and Stability in Serial Prediction
000834560 260__ $$aCambridge, Mass.$$bMIT Pr. Journals$$c2017
000834560 3367_ $$2DRIVER$$aarticle
000834560 3367_ $$2DataCite$$aOutput Types/Journal article
000834560 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1499346260_15391
000834560 3367_ $$2BibTeX$$aARTICLE
000834560 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000834560 3367_ $$00$$2EndNote$$aJournal Article
000834560 520__ $$aSurprising events may be relevant or irrelevant for behavior, requiring either flexible adjustment or stabilization of our model of the world and according response strategies. Cognitive flexibility and stability in response to environmental demands have been described as separable cognitive states, associated with activity of striatal and lateral prefrontal regions, respectively. It so far remains unclear, however, whether these two states act in an antagonistic fashion and which neural mechanisms mediate the selection of respective responses, on the one hand, and a transition between these states, on the other. In this study, we tested whether the functional dichotomy between striatal and prefrontal activity applies for the separate functions of updating (in response to changes in the environment, i.e., switches) and shielding (in response to chance occurrences of events violating expectations, i.e., drifts) of current predictions. We measured brain activity using fMRI while 20 healthy participants performed a task that required to serially predict upcoming items. Switches between predictable sequences had to be indicated via button press while sequence omissions (drifts) had to be ignored. We further varied the probability of switches and drifts to assess the neural network supporting the transition between flexible and stable cognitive states as a function of recent performance history in response to environmental demands. Flexible switching between models was associated with activation in medial pFC (BA 9 and BA 10), whereas stable maintenance of the internal model corresponded to activation in the lateral pFC (BA 6 and inferior frontal gyrus). Our findings extend previous studies on the interplay of flexibility and stability, suggesting that different prefrontal regions are activated by different types of prediction errors, dependent on their behavioral requirements. Furthermore, we found that striatal activation in response to switches and drifts was modulated by participants' successful behavior toward these events, suggesting the striatum to be responsible for response selections following unpredicted stimuli. Finally, we observed that the dopaminergic midbrain modulates the transition between different cognitive states, thresholded by participants' individual performance history in response to temporal environmental demands
000834560 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000834560 588__ $$aDataset connected to CrossRef
000834560 7001_ $$0P:(DE-HGF)0$$aSchiffer, Anne-Marike$$b1
000834560 7001_ $$0P:(DE-HGF)0$$aEl-Sourani, Nadiya$$b2
000834560 7001_ $$0P:(DE-HGF)0$$aAhlheim, Christiane$$b3
000834560 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b4$$ufzj
000834560 7001_ $$0P:(DE-HGF)0$$aSchubotz, Ricarda I.$$b5
000834560 773__ $$0PERI:(DE-600)1475255-4$$a10.1162/jocn_a_01040$$gVol. 29, no. 2, p. 298 - 309$$n2$$p298 - 309$$tJournal of cognitive neuroscience$$v29$$x1530-8898$$y2017
000834560 8564_ $$uhttps://juser.fz-juelich.de/record/834560/files/jocn_a_01040.pdf$$yRestricted
000834560 8564_ $$uhttps://juser.fz-juelich.de/record/834560/files/jocn_a_01040.gif?subformat=icon$$xicon$$yRestricted
000834560 8564_ $$uhttps://juser.fz-juelich.de/record/834560/files/jocn_a_01040.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000834560 8564_ $$uhttps://juser.fz-juelich.de/record/834560/files/jocn_a_01040.jpg?subformat=icon-180$$xicon-180$$yRestricted
000834560 8564_ $$uhttps://juser.fz-juelich.de/record/834560/files/jocn_a_01040.jpg?subformat=icon-640$$xicon-640$$yRestricted
000834560 8564_ $$uhttps://juser.fz-juelich.de/record/834560/files/jocn_a_01040.pdf?subformat=pdfa$$xpdfa$$yRestricted
000834560 909CO $$ooai:juser.fz-juelich.de:834560$$pVDB
000834560 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)169149$$a INM-3$$b0
000834560 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)169149$$aForschungszentrum Jülich$$b0$$kFZJ
000834560 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich$$b4$$kFZJ
000834560 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000834560 9141_ $$y2017
000834560 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ COGNITIVE NEUROSCI : 2015
000834560 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000834560 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000834560 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000834560 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000834560 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000834560 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000834560 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000834560 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000834560 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000834560 915__ $$0StatID:(DE-HGF)0130$$2StatID$$aDBCoverage$$bSocial Sciences Citation Index
000834560 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000834560 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000834560 920__ $$lyes
000834560 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000834560 980__ $$ajournal
000834560 980__ $$aVDB
000834560 980__ $$aI:(DE-Juel1)INM-3-20090406
000834560 980__ $$aUNRESTRICTED