%0 Journal Article
%A Irbäck, Anders
%A Mohanty, Sandipan
%T Protein folding/unfolding in the presence of interacting macromolecular crowders
%J European physical journal special topics
%V 226
%N 4
%@ 1951-6401
%C Berlin
%I Springer
%M FZJ-2017-04489
%P 627 - 638
%D 2017
%X Recent years have seen an increasing number of biophysical studies of proteins being conducted in cells and concentrated protein solutions. In these experiments, compared to dilute-solution data, both stabilization and destabilization of globular proteins have been observed, which cannot be explained in terms of volume exclusion alone. For a fundamental understanding of the observed effects, there is a need for computational modeling beyond the level of hard-sphere crowders. This mini-review discusses recent efforts to simulate folding/unfolding properties of proteins in the presence of explicit macro-molecular crowders. A Monte Carlo-based approach by us is described, which we recently applied to study the equilibrium folding thermodynamics of two peptides in the presence of explicit protein crowders.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000399440100008
%R 10.1140/epjst/e2016-60316-9
%U https://juser.fz-juelich.de/record/834561