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000834561 1001_ $$00000-0003-1384-0626$$aIrbäck, Anders$$b0$$eCorresponding author
000834561 245__ $$aProtein folding/unfolding in the presence of interacting macromolecular crowders
000834561 260__ $$aBerlin$$bSpringer$$c2017
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000834561 520__ $$aRecent years have seen an increasing number of biophysical studies of proteins being conducted in cells and concentrated protein solutions. In these experiments, compared to dilute-solution data, both stabilization and destabilization of globular proteins have been observed, which cannot be explained in terms of volume exclusion alone. For a fundamental understanding of the observed effects, there is a need for computational modeling beyond the level of hard-sphere crowders. This mini-review discusses recent efforts to simulate folding/unfolding properties of proteins in the presence of explicit macro-molecular crowders. A Monte Carlo-based approach by us is described, which we recently applied to study the equilibrium folding thermodynamics of two peptides in the presence of explicit protein crowders.
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000834561 7001_ $$0P:(DE-Juel1)132590$$aMohanty, Sandipan$$b1$$eCorresponding author$$ufzj
000834561 773__ $$0PERI:(DE-600)2267176-6$$a10.1140/epjst/e2016-60316-9$$gVol. 226, no. 4, p. 627 - 638$$n4$$p627 - 638$$tEuropean physical journal special topics$$v226$$x1951-6401$$y2017
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