TY  - JOUR
AU  - Irbäck, Anders
AU  - Mohanty, Sandipan
TI  - Protein folding/unfolding in the presence of interacting macromolecular crowders
JO  - European physical journal special topics
VL  - 226
IS  - 4
SN  - 1951-6401
CY  - Berlin
PB  - Springer
M1  - FZJ-2017-04489
SP  - 627 - 638
PY  - 2017
AB  - Recent years have seen an increasing number of biophysical studies of proteins being conducted in cells and concentrated protein solutions. In these experiments, compared to dilute-solution data, both stabilization and destabilization of globular proteins have been observed, which cannot be explained in terms of volume exclusion alone. For a fundamental understanding of the observed effects, there is a need for computational modeling beyond the level of hard-sphere crowders. This mini-review discusses recent efforts to simulate folding/unfolding properties of proteins in the presence of explicit macro-molecular crowders. A Monte Carlo-based approach by us is described, which we recently applied to study the equilibrium folding thermodynamics of two peptides in the presence of explicit protein crowders.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000399440100008
DO  - DOI:10.1140/epjst/e2016-60316-9
UR  - https://juser.fz-juelich.de/record/834561
ER  -