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@ARTICLE{Irbck:834561,
author = {Irbäck, Anders and Mohanty, Sandipan},
title = {{P}rotein folding/unfolding in the presence of interacting
macromolecular crowders},
journal = {European physical journal special topics},
volume = {226},
number = {4},
issn = {1951-6401},
address = {Berlin},
publisher = {Springer},
reportid = {FZJ-2017-04489},
pages = {627 - 638},
year = {2017},
abstract = {Recent years have seen an increasing number of biophysical
studies of proteins being conducted in cells and
concentrated protein solutions. In these experiments,
compared to dilute-solution data, both stabilization and
destabilization of globular proteins have been observed,
which cannot be explained in terms of volume exclusion
alone. For a fundamental understanding of the observed
effects, there is a need for computational modeling beyond
the level of hard-sphere crowders. This mini-review
discusses recent efforts to simulate folding/unfolding
properties of proteins in the presence of explicit
macro-molecular crowders. A Monte Carlo-based approach by us
is described, which we recently applied to study the
equilibrium folding thermodynamics of two peptides in the
presence of explicit protein crowders.},
cin = {JSC},
ddc = {530},
cid = {I:(DE-Juel1)JSC-20090406},
pnm = {511 - Computational Science and Mathematical Methods
(POF3-511)},
pid = {G:(DE-HGF)POF3-511},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000399440100008},
doi = {10.1140/epjst/e2016-60316-9},
url = {https://juser.fz-juelich.de/record/834561},
}